Intermittent systemic exposure to lipopolysaccharide-induced inflammation disrupts hippocampal long-term potentiation and impairs cognition in aging male mice

•Cognitive impacts of repeated intermittent inflammation are not well studied.•Intermittent exposure to lipopolysaccharide induces moderate sickness from which mice recover.•Repeated intermittent lipopolysaccharide does not induce persistent brain inflammation.•Repeated intermittent lipopolysacchari...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2023-02, Vol.108, p.279-291
Hauptverfasser:	Engler-Chiurazzi, E.B., Russell, A.E., Povroznik, J.M., McDonald, K.O., Porter, K.N., Wang, D.S., Hammock, J., Billig, B.K., Felton, C.C., Yilmaz, A., Schreurs, B.G., O'Callaghan, J.P., Zwezdaryk, K.J., Simpkins, J.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals Brain aging Cognition - physiology Cognitive aging Hippocampus Hippocampus - metabolism Infection burden Inflammation - complications Learning and memory Lipopolysaccharide Lipopolysaccharides - metabolism Lipopolysaccharides - pharmacology Long-Term Potentiation Male Maze Learning Mice Mice, Inbred C57BL Neuroinflammation Quality of Life Synaptic plasticity Systemic inflammation
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