Acquired crizotinib-resistant pulmonary adenocarcinoma and subsequent primary gallbladder cancer: A case report

Proto-oncogene-oriented targeted therapy has limited benefits in elderly patients with multiple primary tumors. A woman with anaplastic lymphoma kinase-positive lung adenocarcinoma developed acquired resistance after 3 years of targeted therapy with crizotinib. Diagnosis of unexpected subsequent pri...

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Veröffentlicht in:	Medicine (Baltimore) 2023-03, Vol.102 (11), p.e33162-e33162
Hauptverfasser:	Zhang, Min, Chen, Ruilin, Zheng, Suqun, Wang, Zhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma of Lung - drug therapy Adenocarcinoma of Lung - genetics Aged Anaplastic Lymphoma Kinase - metabolism Clinical Case Report Crizotinib - therapeutic use Drug Resistance, Neoplasm - genetics Female Gallbladder Neoplasms - drug therapy Gallbladder Neoplasms - genetics Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Mutation Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use
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