The SL autoantibody-antigen system: clinical and biochemical studies

A recently described autoantibody, SL, was found in serum from 27 patients with autoimmune disease, including 20 with systemic lupus erythematosus (SLE) where the frequently was 7%. Analysis of clinical, serological, and HLA data from 119 SLE patients showed no positive associations with anti-SL ant...

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Veröffentlicht in:Annals of the rheumatic diseases 1986-05, Vol.45 (5), p.353-358
Hauptverfasser: Bernstein, R M, Morgan, S H, Bunn, C C, Gainey, R C, Hughes, G R, Mathews, M B
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container_end_page 358
container_issue 5
container_start_page 353
container_title Annals of the rheumatic diseases
container_volume 45
creator Bernstein, R M
Morgan, S H
Bunn, C C
Gainey, R C
Hughes, G R
Mathews, M B
description A recently described autoantibody, SL, was found in serum from 27 patients with autoimmune disease, including 20 with systemic lupus erythematosus (SLE) where the frequently was 7%. Analysis of clinical, serological, and HLA data from 119 SLE patients showed no positive associations with anti-SL antibody apart from a higher frequency of non-infective fever. Most SL positive sera contained other precipitins, notably antibodies to Ro(SS-A) and the proliferating cell nuclear antigen, PCNA. Anti-SL IgG recognised a protein of 32 000 daltons without associated RNA. This polypeptide was distinguished from a similarly sized component of the Sm and RNP ribonucleoprotein particles by demonstrating different products of partial proteolysis. Although anti-SL antibody is of limited clinical importance, it occurs with twice the frequency of anti-SM antibody in white patients with SLE. Preliminary studies indicate that SL and the Japanese Ki system are identical.
doi_str_mv 10.1136/ard.45.5.353
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Analysis of clinical, serological, and HLA data from 119 SLE patients showed no positive associations with anti-SL antibody apart from a higher frequency of non-infective fever. Most SL positive sera contained other precipitins, notably antibodies to Ro(SS-A) and the proliferating cell nuclear antigen, PCNA. Anti-SL IgG recognised a protein of 32 000 daltons without associated RNA. This polypeptide was distinguished from a similarly sized component of the Sm and RNP ribonucleoprotein particles by demonstrating different products of partial proteolysis. Although anti-SL antibody is of limited clinical importance, it occurs with twice the frequency of anti-SM antibody in white patients with SLE. 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subjects Antibodies, Antinuclear - immunology
Autoantibodies - immunology
Autoimmune Diseases - immunology
Biological and medical sciences
Chemical Precipitation
Electrophoresis, Polyacrylamide Gel
Humans
Immunoelectrophoresis
Lupus Erythematosus, Systemic - immunology
Medical sciences
Peptide Fragments - analysis
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
title The SL autoantibody-antigen system: clinical and biochemical studies
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