A riboswitch separated from its ribosome-binding site still regulates translation

Abstract Riboswitches regulate downstream gene expression by binding cellular metabolites. Regulation of translation initiation by riboswitches is posited to occur by metabolite-mediated sequestration of the Shine-Dalgarno sequence (SDS), causing bypass by the ribosome. Recently, we solved a co-crys...

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Veröffentlicht in:	Nucleic acids research 2023-03, Vol.51 (5), p.2464-2484
Hauptverfasser:	Schroeder, Griffin M, Akinyemi, Olayinka, Malik, Jeffrey, Focht, Caroline M, Pritchett, Elizabeth M, Baker, Cameron D, McSally, James P, Jenkins, Jermaine L, Mathews, David H, Wedekind, Joseph E
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Gene Expression Regulation Molecular Dynamics Simulation Nucleic Acid Conformation Protein Biosynthesis Ribosomes - genetics Ribosomes - metabolism Riboswitch Structural Biology
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