Proactive Metabolite Testing in Patients on Thiopurine May Yield Long-Term Clinical Benefits in Inflammatory Bowel Disease

Background The thiopurine medications are well established in the treatment of inflammatory bowel disease (IBD). There is significant variation in levels of toxic and therapeutic metabolites. Current data from small or short-term studies support therapeutic drug monitoring (TDM) in assessing azathio...

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Veröffentlicht in:	Digestive diseases and sciences 2023-03, Vol.68 (3), p.889-896
Hauptverfasser:	Barnes, Alex, Ooi, Soong-Yuan J., Lynch, Kate D., Parthasarathy, Nina, Bishara, Maria, Gounder, Michael, Grafton, Rachel, Leach, Peta, Bampton, Peter, Sechi, Alexandra, Ng, Watson, Connor, Susan, van Langenberg, Daniel, Mountifield, Réme, Andrews, Jane M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Azathioprine Azathioprine - adverse effects Biochemistry Care and treatment Drug dosages Gastroenterology Gastrointestinal diseases Health aspects Hepatology Humans Immunosuppressive Agents - adverse effects Inflammatory bowel disease Inflammatory Bowel Diseases - chemically induced Inflammatory Bowel Diseases - diagnosis Inflammatory Bowel Diseases - drug therapy Medical colleges Medical research Medicine Medicine & Public Health Medicine, Experimental Mercaptopurine Mercaptopurine - adverse effects Metabolites Methylthioinosine - therapeutic use Oncology Original Original Article Political aspects Remission (Medicine) Retrospective Studies Therapeutic drug monitoring Transplant Surgery
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