Effects of immunosuppression on herpes simplex virus growth in lymphocytes of patients with connective tissue diseases
The growth of herpes simplex virus (HSV) was measured in blood lymphocytes isolated from patients with connective tissue diseases receiving immunosuppressive drugs. Whereas lymphocytes from such patients were frequently nonpermissive for HSV before treatment, they became permissive in most patients...
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| Veröffentlicht in: | Annals of the rheumatic diseases 1983-06, Vol.42 (3), p.264-269 |
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| container_issue | 3 |
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| container_title | Annals of the rheumatic diseases |
| container_volume | 42 |
| creator | Hollingworth, P Hylton, W Pelton, B K Denman, A M |
| description | The growth of herpes simplex virus (HSV) was measured in blood lymphocytes isolated from patients with connective tissue diseases receiving immunosuppressive drugs. Whereas lymphocytes from such patients were frequently nonpermissive for HSV before treatment, they became permissive in most patients after treatment. The exception was the persistence of nonpermissiveness in lymphocytes of treated patients whose disease was associated with malignant disease. |
| doi_str_mv | 10.1136/ard.42.3.264 |
| format | Article |
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Whereas lymphocytes from such patients were frequently nonpermissive for HSV before treatment, they became permissive in most patients after treatment. The exception was the persistence of nonpermissiveness in lymphocytes of treated patients whose disease was associated with malignant disease.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/ard.42.3.264</identifier><identifier>PMID: 6305288</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Adult ; Aged ; Connective Tissue Diseases - blood ; Connective Tissue Diseases - complications ; Connective Tissue Diseases - microbiology ; Humans ; Immunosuppressive Agents - pharmacology ; Lymphocytes - drug effects ; Lymphocytes - microbiology ; Middle Aged ; Neoplasms - complications ; Simplexvirus - drug effects ; Simplexvirus - growth & development ; Time Factors ; Virus Replication - drug effects</subject><ispartof>Annals of the rheumatic diseases, 1983-06, Vol.42 (3), p.264-269</ispartof><rights>Copyright BMJ Publishing Group LTD Jun 1983</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b477t-605bc074bf4f935627f1d54bdcef2bdbeb8d259192cbf012a70e9d1f61266e1e3</citedby><cites>FETCH-LOGICAL-b477t-605bc074bf4f935627f1d54bdcef2bdbeb8d259192cbf012a70e9d1f61266e1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1001126/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1001126/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6305288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hollingworth, P</creatorcontrib><creatorcontrib>Hylton, W</creatorcontrib><creatorcontrib>Pelton, B K</creatorcontrib><creatorcontrib>Denman, A M</creatorcontrib><title>Effects of immunosuppression on herpes simplex virus growth in lymphocytes of patients with connective tissue diseases</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>The growth of herpes simplex virus (HSV) was measured in blood lymphocytes isolated from patients with connective tissue diseases receiving immunosuppressive drugs. Whereas lymphocytes from such patients were frequently nonpermissive for HSV before treatment, they became permissive in most patients after treatment. The exception was the persistence of nonpermissiveness in lymphocytes of treated patients whose disease was associated with malignant disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Connective Tissue Diseases - blood</subject><subject>Connective Tissue Diseases - complications</subject><subject>Connective Tissue Diseases - microbiology</subject><subject>Humans</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - microbiology</subject><subject>Middle Aged</subject><subject>Neoplasms - complications</subject><subject>Simplexvirus - drug effects</subject><subject>Simplexvirus - growth & development</subject><subject>Time Factors</subject><subject>Virus Replication - drug effects</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc-L1DAYhoMo67h68yoUBL1sxyRNk_YiyLDuCst68NcxNO2XnYxtUvO1szv_vdmdYVAPQiCE98mTL7yEvGR0yVgh3zWxWwq-LJZcikdkwYSsck4lfUwWlNIiF7VUT8kzxE060opVJ-REFrTkVbUg23NroZ0wCzZzwzD7gPM4RkB0wWdprSGOgBm6YezhLtu6OGN2E8PttM6cz_rdMK5Du5vgQTE2kwOfdLcu5W3wPsndFrLJIc6QdQ6hQcDn5IlteoQXh_2UfPt4_nV1mV99vvi0-nCVG6HUlEtampYqYaywdVFKrizrSmG6Fiw3nQFTdbysWc1bYynjjaJQd8xKxqUEBsUpeb_3jrMZIF3zU2x6PUY3NHGnQ-P034l3a30TtppRypIkCd4cBDH8mgEnPThsoe8bD2FGXdGSKclZAl__A27CHH36nE5ArQoh6nvqbE-1MSBGsMdRGNX3berUphZcFzq1mfBXf45_hA_1pTzf5w4nuDvGTfyppSpUqa-_r_RlXV7I1fUP_SXxb_e8GTb_f_k3nqm67w</recordid><startdate>19830601</startdate><enddate>19830601</enddate><creator>Hollingworth, P</creator><creator>Hylton, W</creator><creator>Pelton, B K</creator><creator>Denman, A M</creator><general>BMJ Publishing Group Ltd and European League Against Rheumatism</general><general>Elsevier Limited</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19830601</creationdate><title>Effects of immunosuppression on herpes simplex virus growth in lymphocytes of patients with connective tissue diseases</title><author>Hollingworth, P ; Hylton, W ; Pelton, B K ; Denman, A M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b477t-605bc074bf4f935627f1d54bdcef2bdbeb8d259192cbf012a70e9d1f61266e1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Connective Tissue Diseases - blood</topic><topic>Connective Tissue Diseases - complications</topic><topic>Connective Tissue Diseases - microbiology</topic><topic>Humans</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - microbiology</topic><topic>Middle Aged</topic><topic>Neoplasms - complications</topic><topic>Simplexvirus - drug effects</topic><topic>Simplexvirus - growth & development</topic><topic>Time Factors</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hollingworth, P</creatorcontrib><creatorcontrib>Hylton, W</creatorcontrib><creatorcontrib>Pelton, B K</creatorcontrib><creatorcontrib>Denman, A M</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hollingworth, P</au><au>Hylton, W</au><au>Pelton, B K</au><au>Denman, A M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of immunosuppression on herpes simplex virus growth in lymphocytes of patients with connective tissue diseases</atitle><jtitle>Annals of the rheumatic diseases</jtitle><addtitle>Ann Rheum Dis</addtitle><date>1983-06-01</date><risdate>1983</risdate><volume>42</volume><issue>3</issue><spage>264</spage><epage>269</epage><pages>264-269</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>The growth of herpes simplex virus (HSV) was measured in blood lymphocytes isolated from patients with connective tissue diseases receiving immunosuppressive drugs. 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| fulltext | fulltext |
| identifier | ISSN: 0003-4967 |
| ispartof | Annals of the rheumatic diseases, 1983-06, Vol.42 (3), p.264-269 |
| issn | 0003-4967 1468-2060 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1001126 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Aged Connective Tissue Diseases - blood Connective Tissue Diseases - complications Connective Tissue Diseases - microbiology Humans Immunosuppressive Agents - pharmacology Lymphocytes - drug effects Lymphocytes - microbiology Middle Aged Neoplasms - complications Simplexvirus - drug effects Simplexvirus - growth & development Time Factors Virus Replication - drug effects |
| title | Effects of immunosuppression on herpes simplex virus growth in lymphocytes of patients with connective tissue diseases |
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