Circulating immune complexes in cutaneous and systemic vasculitis: clinicopathological correlations
A high incidence of raised levels of circulating immune complexes has found in a group of patients with idiopathic vasculitis. Serial measurements in 8 patients with systemic vasculitis showed a good correlation between clinical status and circulating immune complex levels. Some correlation existed...
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| Veröffentlicht in: | Annals of the rheumatic diseases 1982-02, Vol.41 (1), p.25-29 |
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| container_title | Annals of the rheumatic diseases |
| container_volume | 41 |
| creator | Barratt, J Sindrey, M Summerly, R Aber, G M Naish, P |
| description | A high incidence of raised levels of circulating immune complexes has found in a group of patients with idiopathic vasculitis. Serial measurements in 8 patients with systemic vasculitis showed a good correlation between clinical status and circulating immune complex levels. Some correlation existed between the constituents of circulating and tissue-bound complexes in 6 patients so studied. However, there was no correlation between apparent organ involvement and hypocomplementaemia and the levels of size of circulating immune complexes. It is concluded that the measurement of circulating immune complexes may be clinically useful in vasculitis, but that no direct evidence is yet available that they are pathogenetically related to those which are tissue-bound. |
| doi_str_mv | 10.1136/ard.41.1.25 |
| format | Article |
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Serial measurements in 8 patients with systemic vasculitis showed a good correlation between clinical status and circulating immune complex levels. Some correlation existed between the constituents of circulating and tissue-bound complexes in 6 patients so studied. However, there was no correlation between apparent organ involvement and hypocomplementaemia and the levels of size of circulating immune complexes. 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Serial measurements in 8 patients with systemic vasculitis showed a good correlation between clinical status and circulating immune complex levels. Some correlation existed between the constituents of circulating and tissue-bound complexes in 6 patients so studied. However, there was no correlation between apparent organ involvement and hypocomplementaemia and the levels of size of circulating immune complexes. It is concluded that the measurement of circulating immune complexes may be clinically useful in vasculitis, but that no direct evidence is yet available that they are pathogenetically related to those which are tissue-bound.</description><subject>Antigen-Antibody Complex - analysis</subject><subject>Humans</subject><subject>Immunologic Techniques</subject><subject>Kidney - immunology</subject><subject>Skin - immunology</subject><subject>Vasculitis - immunology</subject><subject>Vasculitis, Leukocytoclastic, Cutaneous - immunology</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc1rFDEYxkNR6rb21LMwIHiRWfM5STwIMlgV6he0pbeQyWS32WaSNZkp7X9vll2W1oOeQnh-ed68zwPAKYJzhEjzTqd-TtEczTE7ADNEG1Fj2MBnYAYhJDWVDX8BjnJelSsUSByCQw6JZBjPgGldMpPXowvLyg3DFGxl4rD29t7myoXKTKMONk650qGv8kMe7eBMdadzeeZGl99XxrvgTFzr8Sb6uHRG--KRkt3YxpBfgucL7bM92Z3H4PLs00X7pT7_8flr-_G87hikY6172kDWE9lpgjDGBDYWGyN7BjkU0HDRYSYxQZRK02PDJbVELCy0kiwYQeQYfNj6rqdusL2xYUzaq3Vyg04PKmqnnirB3ahlvFNokwsTxeDNziDF35PNoxpcNtb7bQKK08JRzv4LIsIEJJgW8PVf4CpOKZQUFOKN5FgIhgv1dkuZFHNOdrH_M4JqU7EqFSuKFFJ4M_zV4zX37K7Totdb3ZWu7veyTreq4YQz9f2qVe2vbz9Re32lHi3TDat_Dv4DGjy_DQ</recordid><startdate>19820201</startdate><enddate>19820201</enddate><creator>Barratt, J</creator><creator>Sindrey, M</creator><creator>Summerly, R</creator><creator>Aber, G M</creator><creator>Naish, P</creator><general>BMJ Publishing Group Ltd and European League Against Rheumatism</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19820201</creationdate><title>Circulating immune complexes in cutaneous and systemic vasculitis: clinicopathological correlations</title><author>Barratt, J ; 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| issn | 0003-4967 1468-2060 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Antigen-Antibody Complex - analysis Humans Immunologic Techniques Kidney - immunology Skin - immunology Vasculitis - immunology Vasculitis, Leukocytoclastic, Cutaneous - immunology |
| title | Circulating immune complexes in cutaneous and systemic vasculitis: clinicopathological correlations |
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