Dysregulated Smooth Muscle Cell BMPR2–ARRB2 Axis Causes Pulmonary Hypertension

Mutations in (bone morphogenetic protein receptor 2) are associated with familial and sporadic pulmonary arterial hypertension (PAH). The functional and molecular link between loss of BMPR2 in pulmonary artery smooth muscle cells (PASMC) and PAH pathogenesis warrants further investigation, as most i...

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Veröffentlicht in:	Circulation research 2023-03, Vol.132 (5), p.545-564
Hauptverfasser:	Wang, Lingli, Moonen, Jan-Renier, Cao, Aiqin, Isobe, Sarasa, Li, Caiyun G., Tojais, Nancy F., Taylor, Shalina, Marciano, David P., Chen, Pin-I., Gu, Mingxia, Li, Dan, Harper, Rebecca L., El-Bizri, Nesrine, Kim, Yu-Mee, Stankunas, Kryn, Rabinovitch, Marlene
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Arrestin 2 - metabolism Bone Morphogenetic Protein Receptors, Type II - genetics Bone Morphogenetic Protein Receptors, Type II - metabolism Cell Proliferation Cells, Cultured Endothelial Cells - metabolism Glycogen Synthase Kinase 3 - metabolism Humans Hypertension, Pulmonary - metabolism Hypoxia - complications Hypoxia - genetics Hypoxia - metabolism Mice Myocytes, Smooth Muscle - metabolism Pulmonary Arterial Hypertension - genetics Pulmonary Artery - metabolism RNA - metabolism
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