Biological effects of prostaglandin E2-EP4 antagonist (AAT-008) in murine colon cancer in vivo : enhancement of immune response to radiotherapy and potential as a radiosensitizer

Prostaglandin E2 (PGE2) promotes tumor growth and metastasis by acting on a family of four receptors (EP1-4). We investigated the radiosensitizing effects of a newly developed antagonist of PGE2-EP4 (AAT-008) in mouse colon cancer cells and explored the mechanism using flow cytometry (FCM). CT26WT c...

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Veröffentlicht in:	Translational cancer research 2023-02, Vol.12 (2), p.351-358
Hauptverfasser:	Manabe, Yoshihiko, Takahashi, Yutaka, Sugie, Chikao, Wang, Zhen, Katsuki, Shohei, Kondo, Takuhito, Murai, Taro, Nakashima, Masahiro, Takaoka, Taiki, Ogawa, Kazuhiko, Shibamoto, Yuta
Format:	Artikel
Sprache:	eng
Schlagworte:	Original
Online-Zugang:	Volltext
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