Zinc: From Biological Functions to Therapeutic Potential
The trace element zinc (Zn) displays a wide range of biological functions. Zn ions control intercellular communication and intracellular events that maintain normal physiological processes. These effects are achieved through the modulation of several Zn-dependent proteins, including transcription fa...
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| Veröffentlicht in: | International journal of molecular sciences 2023-03, Vol.24 (5), p.4822 |
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| creator | Costa, Maria Inês Sarmento-Ribeiro, Ana Bela Gonçalves, Ana Cristina |
| description | The trace element zinc (Zn) displays a wide range of biological functions. Zn ions control intercellular communication and intracellular events that maintain normal physiological processes. These effects are achieved through the modulation of several Zn-dependent proteins, including transcription factors and enzymes of key cell signaling pathways, namely those involved in proliferation, apoptosis, and antioxidant defenses. Efficient homeostatic systems carefully regulate intracellular Zn concentrations. However, perturbed Zn homeostasis has been implicated in the pathogenesis of several chronic human diseases, such as cancer, diabetes, depression, Wilson's disease, Alzheimer's disease, and other age-related diseases. This review focuses on Zn's roles in cell proliferation, survival/death, and DNA repair mechanisms, outlines some biological Zn targets, and addresses the therapeutic potential of Zn supplementation in some human diseases. |
| doi_str_mv | 10.3390/ijms24054822 |
| format | Article |
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Zn ions control intercellular communication and intracellular events that maintain normal physiological processes. These effects are achieved through the modulation of several Zn-dependent proteins, including transcription factors and enzymes of key cell signaling pathways, namely those involved in proliferation, apoptosis, and antioxidant defenses. Efficient homeostatic systems carefully regulate intracellular Zn concentrations. However, perturbed Zn homeostasis has been implicated in the pathogenesis of several chronic human diseases, such as cancer, diabetes, depression, Wilson's disease, Alzheimer's disease, and other age-related diseases. 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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Zn ions control intercellular communication and intracellular events that maintain normal physiological processes. These effects are achieved through the modulation of several Zn-dependent proteins, including transcription factors and enzymes of key cell signaling pathways, namely those involved in proliferation, apoptosis, and antioxidant defenses. Efficient homeostatic systems carefully regulate intracellular Zn concentrations. However, perturbed Zn homeostasis has been implicated in the pathogenesis of several chronic human diseases, such as cancer, diabetes, depression, Wilson's disease, Alzheimer's disease, and other age-related diseases. This review focuses on Zn's roles in cell proliferation, survival/death, and DNA repair mechanisms, outlines some biological Zn targets, and addresses the therapeutic potential of Zn supplementation in some human diseases.</description><subject>Alzheimer's disease</subject><subject>Apoptosis</subject><subject>Bioavailability</subject><subject>Biology</subject><subject>Carrier Proteins - metabolism</subject><subject>Cell death</subject><subject>Cell growth</subject><subject>Cell proliferation</subject><subject>Cell signaling</subject><subject>Cellular signal transduction</subject><subject>Communication</subject><subject>Diabetes mellitus</subject><subject>DNA binding proteins</subject><subject>DNA repair</subject><subject>Enzymes</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Homeostasis</subject><subject>Homeostasis - physiology</subject><subject>Humans</subject><subject>Intracellular</subject><subject>Intracellular signalling</subject><subject>Kinases</subject><subject>Ligands</subject><subject>Phosphorylation</subject><subject>Physiological aspects</subject><subject>Physiological effects</subject><subject>Physiological Phenomena</subject><subject>Potassium</subject><subject>Prostate</subject><subject>Proteins</subject><subject>Review</subject><subject>Signal transduction</subject><subject>Trace elements</subject><subject>Trace Elements - metabolism</subject><subject>Transcription factors</subject><subject>Wilson's disease</subject><subject>Zinc</subject><subject>Zinc - metabolism</subject><subject>Zinc in the body</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptks1vEzEQxS0EoiVw44xWcOFAij3-2uWCSkUAqRIcyoWL5fXaiaNdO7W9SP3v6yilpAjNwZb9mzejp4fQS4LPKO3we7-dMjDMWQvwCJ0SBrDEWMjHR_cT9CznLcZAgXdP0QkVHQbg7BS1v3wwH5pVilPzyccxrr3RY7Oagyk-htyU2FxtbNI7Oxdvmh-x2FC8Hp-jJ06P2b64Oxfo5-rz1cXX5eX3L98uzi-Xhktalq4lg3FD37ZmGLQWnRaSYutAEOus1n1rCLNScjNgDlL03FFGNelBEiOdowv08aC7m_vJDqZOT3pUu-QnnW5U1F49_Al-o9bxtyIYYypqLdDrg0LMxatsfLFmY2II1hRFOt7RDir09m5MitezzUVNPhs7jjrYOGcFshW4YwJkRd_8g27jnEI1YU9xIC0j8Jda69EqH1ys25m9qDqXnHQgMLBKnf2HqjXYydcdrfP1_UHDu0ODSTHnZN29EwSrfR7UcR4q_urYvXv4TwDoLaIHrzM</recordid><startdate>20230302</startdate><enddate>20230302</enddate><creator>Costa, Maria Inês</creator><creator>Sarmento-Ribeiro, Ana Bela</creator><creator>Gonçalves, Ana Cristina</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>OTOTI</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4142-4841</orcidid><orcidid>https://orcid.org/0000-0003-1470-4802</orcidid><orcidid>https://orcid.org/0000000241424841</orcidid><orcidid>https://orcid.org/0000000314704802</orcidid></search><sort><creationdate>20230302</creationdate><title>Zinc: From Biological Functions to Therapeutic Potential</title><author>Costa, Maria Inês ; 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| subjects | Alzheimer's disease Apoptosis Bioavailability Biology Carrier Proteins - metabolism Cell death Cell growth Cell proliferation Cell signaling Cellular signal transduction Communication Diabetes mellitus DNA binding proteins DNA repair Enzymes Growth factors Health aspects Homeostasis Homeostasis - physiology Humans Intracellular Intracellular signalling Kinases Ligands Phosphorylation Physiological aspects Physiological effects Physiological Phenomena Potassium Prostate Proteins Review Signal transduction Trace elements Trace Elements - metabolism Transcription factors Wilson's disease Zinc Zinc - metabolism Zinc in the body |
| title | Zinc: From Biological Functions to Therapeutic Potential |
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