Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma
Meningiomas are the most frequently diagnosed primary intracranial tumors in adults. Surgical resection is preferred if the meningioma is accessible; for those that are not suitable for surgical resection, radiotherapy should be considered to improve local tumor control. However, recurrent meningiom...
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| Veröffentlicht in: | International journal of molecular sciences 2023-03, Vol.24 (5), p.4978 |
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| creator | Lan, Tien-Li Lin, Chun-Fu Lee, Yi-Yen Lin, Ko-Han Chang, Feng-Chi Lin, Shih-Chieh Lee, Jia-Cheng Chou, Fong-In Peir, Jinn-Jer Liu, Hong-Ming Mu, Pei-Fan Chen, Yi-Wei |
| description | Meningiomas are the most frequently diagnosed primary intracranial tumors in adults. Surgical resection is preferred if the meningioma is accessible; for those that are not suitable for surgical resection, radiotherapy should be considered to improve local tumor control. However, recurrent meningiomas are challenging to treat, as the recurrent tumor might be located in the previously irradiated area. Boron Neutron Capture Therapy (BNCT) is a highly selective radiotherapy modality in which the cytotoxic effect focuses mainly on cells with increased uptake of boron-containing drugs. In this article, we describe four patients with recurrent meningiomas treated with BNCT in Taiwan. The mean boron-containing drug tumor-to-normal tissue uptake ratio was 4.125, and the tumor mean dose was 29.414 GyE, received via BNCT. The treatment response showed two stable diseases, one partial response, and one complete response. We also introduce and support the effectiveness and safety of BNCT as an alternative salvage treatment for recurrent meningiomas. |
| doi_str_mv | 10.3390/ijms24054978 |
| format | Article |
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Surgical resection is preferred if the meningioma is accessible; for those that are not suitable for surgical resection, radiotherapy should be considered to improve local tumor control. However, recurrent meningiomas are challenging to treat, as the recurrent tumor might be located in the previously irradiated area. Boron Neutron Capture Therapy (BNCT) is a highly selective radiotherapy modality in which the cytotoxic effect focuses mainly on cells with increased uptake of boron-containing drugs. In this article, we describe four patients with recurrent meningiomas treated with BNCT in Taiwan. The mean boron-containing drug tumor-to-normal tissue uptake ratio was 4.125, and the tumor mean dose was 29.414 GyE, received via BNCT. The treatment response showed two stable diseases, one partial response, and one complete response. We also introduce and support the effectiveness and safety of BNCT as an alternative salvage treatment for recurrent meningiomas.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24054978</identifier><identifier>PMID: 36902408</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adult ; Boron ; Boron Compounds ; Boron Neutron Capture Therapy ; Brain cancer ; Brain Neoplasms - drug therapy ; Care and treatment ; Cytotoxicity ; Drug dosages ; Humans ; Males ; Medical prognosis ; Meningeal Neoplasms - pathology ; Meningioma ; Meningioma - pathology ; Metastasis ; Nervous system ; Neutrons ; Nuclear capture ; Patients ; Radiation therapy ; Surgery ; Tumors</subject><ispartof>International journal of molecular sciences, 2023-03, Vol.24 (5), p.4978</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-aae6fc4446454ddf22b0b6b4c83396829f657ab7906217be155adeadc0141a273</citedby><cites>FETCH-LOGICAL-c480t-aae6fc4446454ddf22b0b6b4c83396829f657ab7906217be155adeadc0141a273</cites><orcidid>0000-0003-3709-885X ; 0000-0002-9196-4897 ; 0000-0002-0972-713X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003570/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003570/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36902408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lan, Tien-Li</creatorcontrib><creatorcontrib>Lin, Chun-Fu</creatorcontrib><creatorcontrib>Lee, Yi-Yen</creatorcontrib><creatorcontrib>Lin, Ko-Han</creatorcontrib><creatorcontrib>Chang, Feng-Chi</creatorcontrib><creatorcontrib>Lin, Shih-Chieh</creatorcontrib><creatorcontrib>Lee, Jia-Cheng</creatorcontrib><creatorcontrib>Chou, Fong-In</creatorcontrib><creatorcontrib>Peir, Jinn-Jer</creatorcontrib><creatorcontrib>Liu, Hong-Ming</creatorcontrib><creatorcontrib>Mu, Pei-Fan</creatorcontrib><creatorcontrib>Chen, Yi-Wei</creatorcontrib><title>Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Meningiomas are the most frequently diagnosed primary intracranial tumors in adults. Surgical resection is preferred if the meningioma is accessible; for those that are not suitable for surgical resection, radiotherapy should be considered to improve local tumor control. However, recurrent meningiomas are challenging to treat, as the recurrent tumor might be located in the previously irradiated area. Boron Neutron Capture Therapy (BNCT) is a highly selective radiotherapy modality in which the cytotoxic effect focuses mainly on cells with increased uptake of boron-containing drugs. In this article, we describe four patients with recurrent meningiomas treated with BNCT in Taiwan. The mean boron-containing drug tumor-to-normal tissue uptake ratio was 4.125, and the tumor mean dose was 29.414 GyE, received via BNCT. The treatment response showed two stable diseases, one partial response, and one complete response. 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Surgical resection is preferred if the meningioma is accessible; for those that are not suitable for surgical resection, radiotherapy should be considered to improve local tumor control. However, recurrent meningiomas are challenging to treat, as the recurrent tumor might be located in the previously irradiated area. Boron Neutron Capture Therapy (BNCT) is a highly selective radiotherapy modality in which the cytotoxic effect focuses mainly on cells with increased uptake of boron-containing drugs. In this article, we describe four patients with recurrent meningiomas treated with BNCT in Taiwan. The mean boron-containing drug tumor-to-normal tissue uptake ratio was 4.125, and the tumor mean dose was 29.414 GyE, received via BNCT. The treatment response showed two stable diseases, one partial response, and one complete response. 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| subjects | Adult Boron Boron Compounds Boron Neutron Capture Therapy Brain cancer Brain Neoplasms - drug therapy Care and treatment Cytotoxicity Drug dosages Humans Males Medical prognosis Meningeal Neoplasms - pathology Meningioma Meningioma - pathology Metastasis Nervous system Neutrons Nuclear capture Patients Radiation therapy Surgery Tumors |
| title | Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma |
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