Cyclophilin A Inhibitors Suppress Proliferation and Induce Apoptosis of MKN45 Gastric Cancer Stem-like Cells by Regulating CypA/CD147-Mediated Signaling Pathway

Gastric cancer stem cells (GCSCs) are a subgroup of gastric cancer (GC) cells with high self-renewal and multi-lineage differentiation abilities that lead to tumor initiation, metastasis, drug resistance, and tumor relapse. Therefore, the eradication of GCSCs can contribute to the effective treatmen...

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Veröffentlicht in:	International journal of molecular sciences 2023-03, Vol.24 (5), p.4734
Hauptverfasser:	Cho, Hee Jeong, Jung, Hye Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animals Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Basigin - metabolism Biomarkers Cancer Cancer therapies Care and treatment Caspase CD147 antigen CD44 antigen Cell cycle Cell differentiation Cell proliferation Cell Proliferation - drug effects Cell self-renewal Chemotherapy Chick Embryo Chorioallantoic membrane Colon Cyclophilin A - antagonists & inhibitors Cyclophilin A - metabolism Cyclosporin A Drug resistance Drug therapy Flow cytometry G1 phase Gastric cancer Growth factors Health aspects Humans Integrins Kinases MAP kinase Medical prognosis Metastases Metastasis Molecular modelling Neoplasm Recurrence, Local - drug therapy Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Oct-4 protein Protein kinases Proteins Radiation therapy Signal Transduction Stem cells Stomach cancer Stomach Neoplasms - drug therapy Subgroups Tumors
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