Genetic Determinants of Leisure-Time Physical Activity in the Hungarian General and Roma Populations
Leisure-time physical activity (LTPA) is one of the modifiable lifestyle factors that play an important role in the prevention of non-communicable (especially cardiovascular) diseases. Certain genetic factors predisposing to LTPA have been previously described, but their effects and applicability on...
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| Veröffentlicht in: | International journal of molecular sciences 2023-02, Vol.24 (5), p.4566 |
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| description | Leisure-time physical activity (LTPA) is one of the modifiable lifestyle factors that play an important role in the prevention of non-communicable (especially cardiovascular) diseases. Certain genetic factors predisposing to LTPA have been previously described, but their effects and applicability on different ethnicities are unknown. Our present study aims to investigate the genetic background of LTPA using seven single nucleotide polymorphisms (SNPs) in a sample of 330 individuals from the Hungarian general (HG) and 314 from the Roma population. The LTPA in general and three intensity categories of it (vigorous, moderate, and walking) were examined as binary outcome variables. Allele frequencies were determined, individual correlations of SNPs to LTPA, in general, were determined, and an optimized polygenetic score (oPGS) was created. Our results showed that the allele frequencies of four SNPs differed significantly between the two study groups. The C allele of rs10887741 showed a significant positive correlation with LTPA in general (OR = 1.48, 95% CI: 1.12-1.97;
= 0.006). Three SNPs (rs10887741, rs6022999, and rs7023003) were identified by the process of PGS optimization, whose cumulative effect shows a strong significant positive association with LTPA in general (OR = 1.40, 95% CI: 1.16-1.70;
< 0.001). The oPGS showed a significantly lower value in the Roma population compared with the HG population (oPGS
: 2.19 ± SD: 0.99 vs. oPGS
: 2.70 ± SD: 1.06;
< 0.001). In conclusion, the coexistence of genetic factors that encourage leisure-time physical activity shows a more unfavorable picture among Roma, which may indirectly contribute to their poor health status. |
| doi_str_mv | 10.3390/ijms24054566 |
| format | Article |
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= 0.006). Three SNPs (rs10887741, rs6022999, and rs7023003) were identified by the process of PGS optimization, whose cumulative effect shows a strong significant positive association with LTPA in general (OR = 1.40, 95% CI: 1.16-1.70;
< 0.001). The oPGS showed a significantly lower value in the Roma population compared with the HG population (oPGS
: 2.19 ± SD: 0.99 vs. oPGS
: 2.70 ± SD: 1.06;
< 0.001). In conclusion, the coexistence of genetic factors that encourage leisure-time physical activity shows a more unfavorable picture among Roma, which may indirectly contribute to their poor health status.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24054566</identifier><identifier>PMID: 36901996</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alleles ; Body mass index ; Cardiovascular Diseases - genetics ; Coexistence ; Diabetes ; Education ; Ethnicity - genetics ; Exercise ; Gender differences ; Gene frequency ; Genetic factors ; Humans ; Hungary - epidemiology ; Hypertension ; Leisure ; Leisure Activities ; Lifestyles ; Metabolism ; Nucleotides ; Physical activity ; Physical fitness ; Population ; Risk factors ; Roma - genetics ; Romani people ; Single-nucleotide polymorphism ; Socioeconomic factors ; Type 2 diabetes ; Womens health</subject><ispartof>International journal of molecular sciences, 2023-02, Vol.24 (5), p.4566</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c437t-153849be1fabb6cb993f30c5212fd6555e992f6078c81f86fca15c582a8d1e8e3</cites><orcidid>0000-0002-0733-6637 ; 0000-0002-9679-6669 ; 0000-0001-9256-3756 ; 0000-0001-5539-907X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003125/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003125/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36901996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pikó, Péter</creatorcontrib><creatorcontrib>Bácsné Bába, Éva</creatorcontrib><creatorcontrib>Kósa, Zsigmond</creatorcontrib><creatorcontrib>Sándor, János</creatorcontrib><creatorcontrib>Kovács, Nóra</creatorcontrib><creatorcontrib>Bács, Zoltán</creatorcontrib><creatorcontrib>Ádány, Róza</creatorcontrib><title>Genetic Determinants of Leisure-Time Physical Activity in the Hungarian General and Roma Populations</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Leisure-time physical activity (LTPA) is one of the modifiable lifestyle factors that play an important role in the prevention of non-communicable (especially cardiovascular) diseases. Certain genetic factors predisposing to LTPA have been previously described, but their effects and applicability on different ethnicities are unknown. Our present study aims to investigate the genetic background of LTPA using seven single nucleotide polymorphisms (SNPs) in a sample of 330 individuals from the Hungarian general (HG) and 314 from the Roma population. The LTPA in general and three intensity categories of it (vigorous, moderate, and walking) were examined as binary outcome variables. Allele frequencies were determined, individual correlations of SNPs to LTPA, in general, were determined, and an optimized polygenetic score (oPGS) was created. Our results showed that the allele frequencies of four SNPs differed significantly between the two study groups. The C allele of rs10887741 showed a significant positive correlation with LTPA in general (OR = 1.48, 95% CI: 1.12-1.97;
= 0.006). Three SNPs (rs10887741, rs6022999, and rs7023003) were identified by the process of PGS optimization, whose cumulative effect shows a strong significant positive association with LTPA in general (OR = 1.40, 95% CI: 1.16-1.70;
< 0.001). The oPGS showed a significantly lower value in the Roma population compared with the HG population (oPGS
: 2.19 ± SD: 0.99 vs. oPGS
: 2.70 ± SD: 1.06;
< 0.001). In conclusion, the coexistence of genetic factors that encourage leisure-time physical activity shows a more unfavorable picture among Roma, which may indirectly contribute to their poor health status.</description><subject>Alleles</subject><subject>Body mass index</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Coexistence</subject><subject>Diabetes</subject><subject>Education</subject><subject>Ethnicity - genetics</subject><subject>Exercise</subject><subject>Gender differences</subject><subject>Gene frequency</subject><subject>Genetic factors</subject><subject>Humans</subject><subject>Hungary - epidemiology</subject><subject>Hypertension</subject><subject>Leisure</subject><subject>Leisure Activities</subject><subject>Lifestyles</subject><subject>Metabolism</subject><subject>Nucleotides</subject><subject>Physical activity</subject><subject>Physical fitness</subject><subject>Population</subject><subject>Risk factors</subject><subject>Roma - genetics</subject><subject>Romani people</subject><subject>Single-nucleotide polymorphism</subject><subject>Socioeconomic factors</subject><subject>Type 2 diabetes</subject><subject>Womens health</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkktr3DAUhU1paB7trusi6KaLONHDkq1VGdI2CQwklHQtZPlqRoMtTSU5MP--GpKGSSlaXCF999wHp6o-EnzBmMSXbjMl2mDecCHeVCekobTGWLRvD-7H1WlKG4wpo1y-q46ZkJhIKU6q4Ro8ZGfQN8gQJ-e1zwkFi5bg0hyhfnAToPv1LjmjR7Qw2T26vEPOo7wGdDP7lY5Oe7TXiYXQfkA_w6TRfdjOo84u-PS-OrJ6TPDhOZ5Vv358f7i6qZd317dXi2VtGtbmmnDWNbIHYnXfC9NLySzDhlNC7SA45yAltQK3nemI7YQ1mnDDO6q7gUAH7Kz6-qS7nfsJBgM-l5bUNrpJx50K2qnXP96t1So8KoIxZoTyovDlWSGG3zOkrCaXDIyj9hDmpGjbCSybTpKCfv4H3YQ5-jLfnipNt7I9oFZ6BOW8DaWw2YuqRcuJpFzQplAX_6HKGWByJniwrry_Sjh_SjAxpBTBvgxJsNrbQh3aouCfDhfzAv_1AfsDM1Cysg</recordid><startdate>20230226</startdate><enddate>20230226</enddate><creator>Pikó, Péter</creator><creator>Bácsné Bába, Éva</creator><creator>Kósa, Zsigmond</creator><creator>Sándor, János</creator><creator>Kovács, Nóra</creator><creator>Bács, Zoltán</creator><creator>Ádány, Róza</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0733-6637</orcidid><orcidid>https://orcid.org/0000-0002-9679-6669</orcidid><orcidid>https://orcid.org/0000-0001-9256-3756</orcidid><orcidid>https://orcid.org/0000-0001-5539-907X</orcidid></search><sort><creationdate>20230226</creationdate><title>Genetic Determinants of Leisure-Time Physical Activity in the Hungarian General and Roma Populations</title><author>Pikó, Péter ; 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Certain genetic factors predisposing to LTPA have been previously described, but their effects and applicability on different ethnicities are unknown. Our present study aims to investigate the genetic background of LTPA using seven single nucleotide polymorphisms (SNPs) in a sample of 330 individuals from the Hungarian general (HG) and 314 from the Roma population. The LTPA in general and three intensity categories of it (vigorous, moderate, and walking) were examined as binary outcome variables. Allele frequencies were determined, individual correlations of SNPs to LTPA, in general, were determined, and an optimized polygenetic score (oPGS) was created. Our results showed that the allele frequencies of four SNPs differed significantly between the two study groups. The C allele of rs10887741 showed a significant positive correlation with LTPA in general (OR = 1.48, 95% CI: 1.12-1.97;
= 0.006). Three SNPs (rs10887741, rs6022999, and rs7023003) were identified by the process of PGS optimization, whose cumulative effect shows a strong significant positive association with LTPA in general (OR = 1.40, 95% CI: 1.16-1.70;
< 0.001). The oPGS showed a significantly lower value in the Roma population compared with the HG population (oPGS
: 2.19 ± SD: 0.99 vs. oPGS
: 2.70 ± SD: 1.06;
< 0.001). In conclusion, the coexistence of genetic factors that encourage leisure-time physical activity shows a more unfavorable picture among Roma, which may indirectly contribute to their poor health status.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36901996</pmid><doi>10.3390/ijms24054566</doi><orcidid>https://orcid.org/0000-0002-0733-6637</orcidid><orcidid>https://orcid.org/0000-0002-9679-6669</orcidid><orcidid>https://orcid.org/0000-0001-9256-3756</orcidid><orcidid>https://orcid.org/0000-0001-5539-907X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Alleles Body mass index Cardiovascular Diseases - genetics Coexistence Diabetes Education Ethnicity - genetics Exercise Gender differences Gene frequency Genetic factors Humans Hungary - epidemiology Hypertension Leisure Leisure Activities Lifestyles Metabolism Nucleotides Physical activity Physical fitness Population Risk factors Roma - genetics Romani people Single-nucleotide polymorphism Socioeconomic factors Type 2 diabetes Womens health |
| title | Genetic Determinants of Leisure-Time Physical Activity in the Hungarian General and Roma Populations |
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