Influence of Genetic Variations in miRNA and Genes Encoding Proteins in the miRNA Synthesis Complex on Toxicity of the Treatment of Pediatric B-Cell ALL in the Brazilian Amazon
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer in the world. Single nucleotide variants (SNVs) in miRNA and genes encoding proteins of the miRNA synthesis complex (SC) may affect the processing of drugs used in the treatment of ALL, resulting in treatment-related toxicities (...
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| Veröffentlicht in: | International journal of molecular sciences 2023-02, Vol.24 (5), p.4431 |
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| creator | da Silva Menezes, Elisa de Moraes, Francisco Cezar Aquino de Nazaré Cohen-Paes, Amanda Wanderley, Alayde Vieira Pereira, Esdras Edgar Batista Pastana, Lucas Favacho Modesto, Antônio André Conde de Assumpção, Paulo Pimentel Burbano, Rommel Mario Rodríguez Dos Santos, Sidney Emanuel Batista Dos Santos, Ney Pereira Carneiro Fernandes, Marianne Rodrigues |
| description | Acute lymphoblastic leukemia (ALL) is the most common childhood cancer in the world. Single nucleotide variants (SNVs) in miRNA and genes encoding proteins of the miRNA synthesis complex (SC) may affect the processing of drugs used in the treatment of ALL, resulting in treatment-related toxicities (TRTs). We investigated the role of 25 SNVs in microRNA genes and genes encoding proteins of the miRNA SC, in 77 patients treated for ALL-B from the Brazilian Amazon. The 25 SNVs were investigated using the TaqMan
OpenArray™ Genotyping System. SNVs rs2292832 (
), rs2043556 (
), and rs10505168 (
) were associated with an increased risk of developing Neurological Toxicity, while rs2505901 (
) was associated with protection from this toxicity.
(rs10505168) and
(rs56103835) were associated with protection from gastrointestinal toxicity, while
(rs639174) increased the risk of development. The rs2043556 (
) variant was related to protection from infectious toxicity. SNVs rs12904 (
), rs3746444 (
), and rs10739971 (
) were associated with a lower risk for severe hematologic toxicity during ALL treatment. These findings reveal the potential for the use of these genetic variants to understand the development of toxicities related to the treatment of ALL in patients from the Brazilian Amazon region. |
| doi_str_mv | 10.3390/ijms24054431 |
| format | Article |
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OpenArray™ Genotyping System. SNVs rs2292832 (
), rs2043556 (
), and rs10505168 (
) were associated with an increased risk of developing Neurological Toxicity, while rs2505901 (
) was associated with protection from this toxicity.
(rs10505168) and
(rs56103835) were associated with protection from gastrointestinal toxicity, while
(rs639174) increased the risk of development. The rs2043556 (
) variant was related to protection from infectious toxicity. SNVs rs12904 (
), rs3746444 (
), and rs10739971 (
) were associated with a lower risk for severe hematologic toxicity during ALL treatment. These findings reveal the potential for the use of these genetic variants to understand the development of toxicities related to the treatment of ALL in patients from the Brazilian Amazon region.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24054431</identifier><identifier>PMID: 36901860</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acute lymphoblastic leukemia ; Brazil ; Cancer therapies ; Child ; Children ; Genes ; Genetic aspects ; Genetic diversity ; Genotype & phenotype ; Genotyping ; Hematology ; Humans ; Investigations ; Leukemia ; Lymphatic leukemia ; Lymphocytes B ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; miRNA ; Mucositis ; Nucleotides ; Patients ; Pediatrics ; Polymorphism ; Polymorphism, Single Nucleotide ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Proteins ; Risk ; Toxicity</subject><ispartof>International journal of molecular sciences, 2023-02, Vol.24 (5), p.4431</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-8531f59391622f620768a09d0e570648a7d4ffa8c4ba343688a3e80cb05c4c4a3</citedby><cites>FETCH-LOGICAL-c480t-8531f59391622f620768a09d0e570648a7d4ffa8c4ba343688a3e80cb05c4c4a3</cites><orcidid>0000-0003-4830-4233 ; 0000-0002-1396-3442 ; 0000-0003-3548-292X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003057/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003057/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36901860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>da Silva Menezes, Elisa</creatorcontrib><creatorcontrib>de Moraes, Francisco Cezar Aquino</creatorcontrib><creatorcontrib>de Nazaré Cohen-Paes, Amanda</creatorcontrib><creatorcontrib>Wanderley, Alayde Vieira</creatorcontrib><creatorcontrib>Pereira, Esdras Edgar Batista</creatorcontrib><creatorcontrib>Pastana, Lucas Favacho</creatorcontrib><creatorcontrib>Modesto, Antônio André Conde</creatorcontrib><creatorcontrib>de Assumpção, Paulo Pimentel</creatorcontrib><creatorcontrib>Burbano, Rommel Mario Rodríguez</creatorcontrib><creatorcontrib>Dos Santos, Sidney Emanuel Batista</creatorcontrib><creatorcontrib>Dos Santos, Ney Pereira Carneiro</creatorcontrib><creatorcontrib>Fernandes, Marianne Rodrigues</creatorcontrib><title>Influence of Genetic Variations in miRNA and Genes Encoding Proteins in the miRNA Synthesis Complex on Toxicity of the Treatment of Pediatric B-Cell ALL in the Brazilian Amazon</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Acute lymphoblastic leukemia (ALL) is the most common childhood cancer in the world. Single nucleotide variants (SNVs) in miRNA and genes encoding proteins of the miRNA synthesis complex (SC) may affect the processing of drugs used in the treatment of ALL, resulting in treatment-related toxicities (TRTs). We investigated the role of 25 SNVs in microRNA genes and genes encoding proteins of the miRNA SC, in 77 patients treated for ALL-B from the Brazilian Amazon. The 25 SNVs were investigated using the TaqMan
OpenArray™ Genotyping System. SNVs rs2292832 (
), rs2043556 (
), and rs10505168 (
) were associated with an increased risk of developing Neurological Toxicity, while rs2505901 (
) was associated with protection from this toxicity.
(rs10505168) and
(rs56103835) were associated with protection from gastrointestinal toxicity, while
(rs639174) increased the risk of development. The rs2043556 (
) variant was related to protection from infectious toxicity. SNVs rs12904 (
), rs3746444 (
), and rs10739971 (
) were associated with a lower risk for severe hematologic toxicity during ALL treatment. These findings reveal the potential for the use of these genetic variants to understand the development of toxicities related to the treatment of ALL in patients from the Brazilian Amazon region.</description><subject>Acute lymphoblastic leukemia</subject><subject>Brazil</subject><subject>Cancer therapies</subject><subject>Child</subject><subject>Children</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic diversity</subject><subject>Genotype & phenotype</subject><subject>Genotyping</subject><subject>Hematology</subject><subject>Humans</subject><subject>Investigations</subject><subject>Leukemia</subject><subject>Lymphatic leukemia</subject><subject>Lymphocytes B</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>Mucositis</subject><subject>Nucleotides</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Proteins</subject><subject>Risk</subject><subject>Toxicity</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1vEzEQhlcIREvhxhlZ4sKBLeOP9e6eUBqVUimCCgJXy_HOpo527dTeoKa_ip-Il6RVipAPtsfPvK_Hnix7TeGU8xo-2FUfmYBCCE6fZMdUMJYDyPLpwfooexHjCoBxVtTPsyMua6CVhOPs96Vruw06g8S35AIdDtaQnzpYPVjvIrGO9PbblwnRrvl7Hsm5M76xbkmugh_Q7qDhGvfg961Lm2gjmfp-3eEt8Y7M_a01dtiOLiM6D6iHHt0wBq6wSXYhGZ_lU-w6MpnN7jXPgr6zndWOTHp9593L7Fmru4iv9vNJ9uPT-Xz6OZ99vbicTma5ERUMeVVw2hY1r6lkrJUMSllpqBvAogQpKl02om11ZcRCc8FlVWmOFZgFFEYYoflJ9nGnu94semxMumrQnVoH2-uwVV5b9fjE2Wu19L8UBQAORZkU3u0Vgr_ZYBxUb6NJ5WmHfhMVKytJ05dQmdC3_6Arvwku1TdSBaN1LQ-ope5QWdf6ZGxGUTUpC1qzsQcSdfofKo0Ge2u8w9am-KOE97sEE3yMAduHIimoscXUYYsl_M3hwzzA9z3F_wDeC8uh</recordid><startdate>20230223</startdate><enddate>20230223</enddate><creator>da Silva Menezes, Elisa</creator><creator>de Moraes, Francisco Cezar Aquino</creator><creator>de Nazaré Cohen-Paes, Amanda</creator><creator>Wanderley, Alayde Vieira</creator><creator>Pereira, Esdras Edgar Batista</creator><creator>Pastana, Lucas Favacho</creator><creator>Modesto, Antônio André Conde</creator><creator>de Assumpção, Paulo Pimentel</creator><creator>Burbano, Rommel Mario Rodríguez</creator><creator>Dos Santos, Sidney Emanuel Batista</creator><creator>Dos Santos, Ney Pereira Carneiro</creator><creator>Fernandes, Marianne Rodrigues</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4830-4233</orcidid><orcidid>https://orcid.org/0000-0002-1396-3442</orcidid><orcidid>https://orcid.org/0000-0003-3548-292X</orcidid></search><sort><creationdate>20230223</creationdate><title>Influence of Genetic Variations in miRNA and Genes Encoding Proteins in the miRNA Synthesis Complex on Toxicity of the Treatment of Pediatric B-Cell ALL in the Brazilian Amazon</title><author>da Silva Menezes, Elisa ; de Moraes, Francisco Cezar Aquino ; de Nazaré Cohen-Paes, Amanda ; Wanderley, Alayde Vieira ; Pereira, Esdras Edgar Batista ; Pastana, Lucas Favacho ; Modesto, Antônio André Conde ; de Assumpção, Paulo Pimentel ; Burbano, Rommel Mario Rodríguez ; Dos Santos, Sidney Emanuel Batista ; Dos Santos, Ney Pereira Carneiro ; Fernandes, Marianne Rodrigues</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-8531f59391622f620768a09d0e570648a7d4ffa8c4ba343688a3e80cb05c4c4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acute lymphoblastic leukemia</topic><topic>Brazil</topic><topic>Cancer therapies</topic><topic>Child</topic><topic>Children</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic diversity</topic><topic>Genotype & phenotype</topic><topic>Genotyping</topic><topic>Hematology</topic><topic>Humans</topic><topic>Investigations</topic><topic>Leukemia</topic><topic>Lymphatic leukemia</topic><topic>Lymphocytes B</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>miRNA</topic><topic>Mucositis</topic><topic>Nucleotides</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Proteins</topic><topic>Risk</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>da Silva Menezes, Elisa</creatorcontrib><creatorcontrib>de Moraes, Francisco Cezar Aquino</creatorcontrib><creatorcontrib>de Nazaré Cohen-Paes, Amanda</creatorcontrib><creatorcontrib>Wanderley, Alayde Vieira</creatorcontrib><creatorcontrib>Pereira, Esdras Edgar Batista</creatorcontrib><creatorcontrib>Pastana, Lucas Favacho</creatorcontrib><creatorcontrib>Modesto, Antônio André Conde</creatorcontrib><creatorcontrib>de Assumpção, Paulo Pimentel</creatorcontrib><creatorcontrib>Burbano, Rommel Mario Rodríguez</creatorcontrib><creatorcontrib>Dos Santos, Sidney Emanuel Batista</creatorcontrib><creatorcontrib>Dos Santos, Ney Pereira Carneiro</creatorcontrib><creatorcontrib>Fernandes, Marianne Rodrigues</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>da Silva Menezes, Elisa</au><au>de Moraes, Francisco Cezar Aquino</au><au>de Nazaré Cohen-Paes, Amanda</au><au>Wanderley, Alayde Vieira</au><au>Pereira, Esdras Edgar Batista</au><au>Pastana, Lucas Favacho</au><au>Modesto, Antônio André Conde</au><au>de Assumpção, Paulo Pimentel</au><au>Burbano, Rommel Mario Rodríguez</au><au>Dos Santos, Sidney Emanuel Batista</au><au>Dos Santos, Ney Pereira Carneiro</au><au>Fernandes, Marianne Rodrigues</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Genetic Variations in miRNA and Genes Encoding Proteins in the miRNA Synthesis Complex on Toxicity of the Treatment of Pediatric B-Cell ALL in the Brazilian Amazon</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2023-02-23</date><risdate>2023</risdate><volume>24</volume><issue>5</issue><spage>4431</spage><pages>4431-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Acute lymphoblastic leukemia (ALL) is the most common childhood cancer in the world. Single nucleotide variants (SNVs) in miRNA and genes encoding proteins of the miRNA synthesis complex (SC) may affect the processing of drugs used in the treatment of ALL, resulting in treatment-related toxicities (TRTs). We investigated the role of 25 SNVs in microRNA genes and genes encoding proteins of the miRNA SC, in 77 patients treated for ALL-B from the Brazilian Amazon. The 25 SNVs were investigated using the TaqMan
OpenArray™ Genotyping System. SNVs rs2292832 (
), rs2043556 (
), and rs10505168 (
) were associated with an increased risk of developing Neurological Toxicity, while rs2505901 (
) was associated with protection from this toxicity.
(rs10505168) and
(rs56103835) were associated with protection from gastrointestinal toxicity, while
(rs639174) increased the risk of development. The rs2043556 (
) variant was related to protection from infectious toxicity. SNVs rs12904 (
), rs3746444 (
), and rs10739971 (
) were associated with a lower risk for severe hematologic toxicity during ALL treatment. These findings reveal the potential for the use of these genetic variants to understand the development of toxicities related to the treatment of ALL in patients from the Brazilian Amazon region.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36901860</pmid><doi>10.3390/ijms24054431</doi><orcidid>https://orcid.org/0000-0003-4830-4233</orcidid><orcidid>https://orcid.org/0000-0002-1396-3442</orcidid><orcidid>https://orcid.org/0000-0003-3548-292X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2023-02, Vol.24 (5), p.4431 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Acute lymphoblastic leukemia Brazil Cancer therapies Child Children Genes Genetic aspects Genetic diversity Genotype & phenotype Genotyping Hematology Humans Investigations Leukemia Lymphatic leukemia Lymphocytes B MicroRNA MicroRNAs MicroRNAs - genetics miRNA Mucositis Nucleotides Patients Pediatrics Polymorphism Polymorphism, Single Nucleotide Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Proteins Risk Toxicity |
| title | Influence of Genetic Variations in miRNA and Genes Encoding Proteins in the miRNA Synthesis Complex on Toxicity of the Treatment of Pediatric B-Cell ALL in the Brazilian Amazon |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T20%3A12%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20Genetic%20Variations%20in%20miRNA%20and%20Genes%20Encoding%20Proteins%20in%20the%20miRNA%20Synthesis%20Complex%20on%20Toxicity%20of%20the%20Treatment%20of%20Pediatric%20B-Cell%20ALL%20in%20the%20Brazilian%20Amazon&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=da%20Silva%20Menezes,%20Elisa&rft.date=2023-02-23&rft.volume=24&rft.issue=5&rft.spage=4431&rft.pages=4431-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms24054431&rft_dat=%3Cgale_pubme%3EA751925443%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2785219966&rft_id=info:pmid/36901860&rft_galeid=A751925443&rfr_iscdi=true |