Mesenchymal Stem Cells in Acquired Aplastic Anemia: The Spectrum from Basic to Clinical Utility
Aplastic anemia (AA), a rare but potentially life-threatening disease, is a paradigm of bone marrow failure syndromes characterized by pancytopenia in the peripheral blood and hypocellularity in the bone marrow. The pathophysiology of acquired idiopathic AA is quite complex. Mesenchymal stem cells (...
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| Veröffentlicht in: | International journal of molecular sciences 2023-02, Vol.24 (5), p.4464 |
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| description | Aplastic anemia (AA), a rare but potentially life-threatening disease, is a paradigm of bone marrow failure syndromes characterized by pancytopenia in the peripheral blood and hypocellularity in the bone marrow. The pathophysiology of acquired idiopathic AA is quite complex. Mesenchymal stem cells (MSCs), an important component of the bone marrow, are crucial in providing the specialized microenvironment for hematopoiesis. MSC dysfunction may result in an insufficient bone marrow and may be associated with the development of AA. In this comprehensive review, we summarized the current understanding about the involvement of MSCs in the pathogenesis of acquired idiopathic AA, along with the clinical application of MSCs for patients with the disease. The pathophysiology of AA, the major properties of MSCs, and results of MSC therapy in preclinical animal models of AA are also described. Several important issues regarding the clinical use of MSCs are discussed finally. With evolving knowledge from basic studies and clinical applications, we anticipate that more patients with the disease can benefit from the therapeutic effects of MSCs in the near future. |
| doi_str_mv | 10.3390/ijms24054464 |
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The pathophysiology of acquired idiopathic AA is quite complex. Mesenchymal stem cells (MSCs), an important component of the bone marrow, are crucial in providing the specialized microenvironment for hematopoiesis. MSC dysfunction may result in an insufficient bone marrow and may be associated with the development of AA. In this comprehensive review, we summarized the current understanding about the involvement of MSCs in the pathogenesis of acquired idiopathic AA, along with the clinical application of MSCs for patients with the disease. The pathophysiology of AA, the major properties of MSCs, and results of MSC therapy in preclinical animal models of AA are also described. Several important issues regarding the clinical use of MSCs are discussed finally. With evolving knowledge from basic studies and clinical applications, we anticipate that more patients with the disease can benefit from the therapeutic effects of MSCs in the near future.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24054464</identifier><identifier>PMID: 36901900</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Anemia ; Anemia, Aplastic - pathology ; Animal models ; Animals ; Antigens ; Aplastic anemia ; Apoptosis ; Bone marrow ; Bone Marrow - pathology ; Cell cycle ; Clinical outcomes ; Cytokines ; Cytotoxicity ; Disease ; Extracellular matrix ; Granulocytes ; Hematopoiesis ; Hemopoiesis ; Lymphocytes ; Mesenchymal stem cells ; Mesenchymal Stem Cells - physiology ; Microenvironments ; Mutation ; Pancytopenia ; Pathogenesis ; Pathophysiology ; Peripheral blood ; Review ; Stem cells ; Tumor necrosis factor-TNF</subject><ispartof>International journal of molecular sciences, 2023-02, Vol.24 (5), p.4464</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-4d73469237bcbb1ffea16c8da81cd8d896c5f0758e9462bdfadfd6bf0abe29b83</citedby><cites>FETCH-LOGICAL-c480t-4d73469237bcbb1ffea16c8da81cd8d896c5f0758e9462bdfadfd6bf0abe29b83</cites><orcidid>0000-0003-4855-8671 ; 0000-0002-0365-7927 ; 0000-0003-1727-5847 ; 0000-0003-3406-4865</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003043/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003043/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36901900$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xing-An</creatorcontrib><creatorcontrib>Li, Ju-Pi</creatorcontrib><creatorcontrib>Wu, Kang-Hsi</creatorcontrib><creatorcontrib>Yang, Shun-Fa</creatorcontrib><creatorcontrib>Chao, Yu-Hua</creatorcontrib><title>Mesenchymal Stem Cells in Acquired Aplastic Anemia: The Spectrum from Basic to Clinical Utility</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Aplastic anemia (AA), a rare but potentially life-threatening disease, is a paradigm of bone marrow failure syndromes characterized by pancytopenia in the peripheral blood and hypocellularity in the bone marrow. The pathophysiology of acquired idiopathic AA is quite complex. Mesenchymal stem cells (MSCs), an important component of the bone marrow, are crucial in providing the specialized microenvironment for hematopoiesis. MSC dysfunction may result in an insufficient bone marrow and may be associated with the development of AA. In this comprehensive review, we summarized the current understanding about the involvement of MSCs in the pathogenesis of acquired idiopathic AA, along with the clinical application of MSCs for patients with the disease. The pathophysiology of AA, the major properties of MSCs, and results of MSC therapy in preclinical animal models of AA are also described. Several important issues regarding the clinical use of MSCs are discussed finally. With evolving knowledge from basic studies and clinical applications, we anticipate that more patients with the disease can benefit from the therapeutic effects of MSCs in the near future.</description><subject>Anemia</subject><subject>Anemia, Aplastic - pathology</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antigens</subject><subject>Aplastic anemia</subject><subject>Apoptosis</subject><subject>Bone marrow</subject><subject>Bone Marrow - pathology</subject><subject>Cell cycle</subject><subject>Clinical outcomes</subject><subject>Cytokines</subject><subject>Cytotoxicity</subject><subject>Disease</subject><subject>Extracellular matrix</subject><subject>Granulocytes</subject><subject>Hematopoiesis</subject><subject>Hemopoiesis</subject><subject>Lymphocytes</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchymal Stem Cells - physiology</subject><subject>Microenvironments</subject><subject>Mutation</subject><subject>Pancytopenia</subject><subject>Pathogenesis</subject><subject>Pathophysiology</subject><subject>Peripheral blood</subject><subject>Review</subject><subject>Stem cells</subject><subject>Tumor necrosis factor-TNF</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1r3DAQhk1paT7aW89F0EsP2VRflq1egrO0SSGlhyRnIUujrBZb2kh2Yf99tCRNN6UIoUHzzDvMy1TVB4JPGZP4i1-PmXJccy74q-qQcEoXGIvm9V58UB3lvMaYMlrLt9UBExITifFhpX5ChmBW21EP6HqCES1hGDLyAXXmfvYJLOo2g86TN6gLMHr9Fd2sAF1vwExpHpFLcUTnOpf8FNFy8MGbonU7-cFP23fVG6eHDO-f3uPq9vu3m-Xl4urXxY9ld7UwvMXTgtuGcSEpa3rT98Q50ESY1uqWGNvaVgpTO9zULUguaG-dts6K3mHdA5V9y46rs0fdzdyPYA2EKelBbZIfddqqqL16mQl-pe7ib0UwxgxzVhQ-PymkeD9DntTosylm6ABxzoo2rcCS13TX7NM_6DrOKZT5dlRNSV3uX-pOD6B8cLE0NjtR1TU1kbTmjSjU6X-ocmzx2sQAzpf_FwUnjwUmxZwTuOchCVa7jVD7G1Hwj_vGPMN_VoA9AFwwsTg</recordid><startdate>20230224</startdate><enddate>20230224</enddate><creator>Wang, Xing-An</creator><creator>Li, Ju-Pi</creator><creator>Wu, Kang-Hsi</creator><creator>Yang, Shun-Fa</creator><creator>Chao, Yu-Hua</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4855-8671</orcidid><orcidid>https://orcid.org/0000-0002-0365-7927</orcidid><orcidid>https://orcid.org/0000-0003-1727-5847</orcidid><orcidid>https://orcid.org/0000-0003-3406-4865</orcidid></search><sort><creationdate>20230224</creationdate><title>Mesenchymal Stem Cells in Acquired Aplastic Anemia: The Spectrum from Basic to Clinical Utility</title><author>Wang, Xing-An ; Li, Ju-Pi ; Wu, Kang-Hsi ; Yang, Shun-Fa ; Chao, Yu-Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-4d73469237bcbb1ffea16c8da81cd8d896c5f0758e9462bdfadfd6bf0abe29b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anemia</topic><topic>Anemia, Aplastic - pathology</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antigens</topic><topic>Aplastic anemia</topic><topic>Apoptosis</topic><topic>Bone marrow</topic><topic>Bone Marrow - pathology</topic><topic>Cell cycle</topic><topic>Clinical outcomes</topic><topic>Cytokines</topic><topic>Cytotoxicity</topic><topic>Disease</topic><topic>Extracellular matrix</topic><topic>Granulocytes</topic><topic>Hematopoiesis</topic><topic>Hemopoiesis</topic><topic>Lymphocytes</topic><topic>Mesenchymal stem cells</topic><topic>Mesenchymal Stem Cells - physiology</topic><topic>Microenvironments</topic><topic>Mutation</topic><topic>Pancytopenia</topic><topic>Pathogenesis</topic><topic>Pathophysiology</topic><topic>Peripheral blood</topic><topic>Review</topic><topic>Stem cells</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xing-An</creatorcontrib><creatorcontrib>Li, Ju-Pi</creatorcontrib><creatorcontrib>Wu, Kang-Hsi</creatorcontrib><creatorcontrib>Yang, Shun-Fa</creatorcontrib><creatorcontrib>Chao, Yu-Hua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xing-An</au><au>Li, Ju-Pi</au><au>Wu, Kang-Hsi</au><au>Yang, Shun-Fa</au><au>Chao, Yu-Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mesenchymal Stem Cells in Acquired Aplastic Anemia: The Spectrum from Basic to Clinical Utility</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2023-02-24</date><risdate>2023</risdate><volume>24</volume><issue>5</issue><spage>4464</spage><pages>4464-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Aplastic anemia (AA), a rare but potentially life-threatening disease, is a paradigm of bone marrow failure syndromes characterized by pancytopenia in the peripheral blood and hypocellularity in the bone marrow. The pathophysiology of acquired idiopathic AA is quite complex. Mesenchymal stem cells (MSCs), an important component of the bone marrow, are crucial in providing the specialized microenvironment for hematopoiesis. MSC dysfunction may result in an insufficient bone marrow and may be associated with the development of AA. In this comprehensive review, we summarized the current understanding about the involvement of MSCs in the pathogenesis of acquired idiopathic AA, along with the clinical application of MSCs for patients with the disease. The pathophysiology of AA, the major properties of MSCs, and results of MSC therapy in preclinical animal models of AA are also described. Several important issues regarding the clinical use of MSCs are discussed finally. With evolving knowledge from basic studies and clinical applications, we anticipate that more patients with the disease can benefit from the therapeutic effects of MSCs in the near future.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36901900</pmid><doi>10.3390/ijms24054464</doi><orcidid>https://orcid.org/0000-0003-4855-8671</orcidid><orcidid>https://orcid.org/0000-0002-0365-7927</orcidid><orcidid>https://orcid.org/0000-0003-1727-5847</orcidid><orcidid>https://orcid.org/0000-0003-3406-4865</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anemia Anemia, Aplastic - pathology Animal models Animals Antigens Aplastic anemia Apoptosis Bone marrow Bone Marrow - pathology Cell cycle Clinical outcomes Cytokines Cytotoxicity Disease Extracellular matrix Granulocytes Hematopoiesis Hemopoiesis Lymphocytes Mesenchymal stem cells Mesenchymal Stem Cells - physiology Microenvironments Mutation Pancytopenia Pathogenesis Pathophysiology Peripheral blood Review Stem cells Tumor necrosis factor-TNF |
| title | Mesenchymal Stem Cells in Acquired Aplastic Anemia: The Spectrum from Basic to Clinical Utility |
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