CCR5∆32 and SDF1 3′A: Gene Variants, Expression and Influence on Biological Markers for the Clinical Progression to AIDS among HIV-1 Virus Controllers in a Mixed Population of the Amazon Region of Brazil

CCR5Δ32 and SDF1-3′A polymorphisms were investigated in a cohort of viremia controllers, without the use of therapy, along with their influence on CD4+ T lymphocytes (TLs), CD8+ TLs, and plasma viral load (VL). The samples were analyzed from 32 HIV-1-infected individuals classified as viremia contro...

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Veröffentlicht in:International journal of molecular sciences 2023-03, Vol.24 (5), p.4958
Hauptverfasser: Lima, Érica Ribeiro Gomes, Queiroz, Maria Alice Freitas, Lima, Sandra Souza, Machado, Luiz Fernando Almeida, Cayres-Vallinoto, Izaura Maria Vieira, Vallinoto, Antonio Carlos Rosário, Figueiredo, Fernanda Andreza de Pinho Lott, Guerreiro, João Farias, Guimarães Ishak, Marluísa de Oliveira, Ishak, Ricardo
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container_issue 5
container_start_page 4958
container_title International journal of molecular sciences
container_volume 24
creator Lima, Érica Ribeiro Gomes
Queiroz, Maria Alice Freitas
Lima, Sandra Souza
Machado, Luiz Fernando Almeida
Cayres-Vallinoto, Izaura Maria Vieira
Vallinoto, Antonio Carlos Rosário
Figueiredo, Fernanda Andreza de Pinho Lott
Guerreiro, João Farias
Guimarães Ishak, Marluísa de Oliveira
Ishak, Ricardo
description CCR5Δ32 and SDF1-3′A polymorphisms were investigated in a cohort of viremia controllers, without the use of therapy, along with their influence on CD4+ T lymphocytes (TLs), CD8+ TLs, and plasma viral load (VL). The samples were analyzed from 32 HIV-1-infected individuals classified as viremia controllers 1 and 2 and viremia non-controllers, from both sexes, mostly heterosexuals, paired with 300 individuals from a control group. CCR5∆32 polymorphism was identified by PCR amplification of a fragment of 189 bp for the wild-type allele and 157 bp for the allele with the ∆32 deletion. SDF1-3′A polymorphism was identified by PCR, followed by enzymatic digestion (restriction fragment length polymorphism) with the Msp I enzyme. The relative quantification of gene expression was performed by real-time PCR. The distribution of allele and genotype frequencies did not show significant differences between the groups. The gene expression of CCR5 and SDF1 was not different between the profiles of AIDS progression. There was no significant correlation between the progression markers (CD4+ TL/CD8+ TL and VL) and the CCR5∆32 polymorphism carrier status. The 3′A allele variant was associated with a marked loss of CD4+ TLs and a higher plasma VL. Neither CCR5∆32 nor SDF1-3′A was associated with viremia control or the controlling phenotype.
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The samples were analyzed from 32 HIV-1-infected individuals classified as viremia controllers 1 and 2 and viremia non-controllers, from both sexes, mostly heterosexuals, paired with 300 individuals from a control group. CCR5∆32 polymorphism was identified by PCR amplification of a fragment of 189 bp for the wild-type allele and 157 bp for the allele with the ∆32 deletion. SDF1-3′A polymorphism was identified by PCR, followed by enzymatic digestion (restriction fragment length polymorphism) with the Msp I enzyme. The relative quantification of gene expression was performed by real-time PCR. The distribution of allele and genotype frequencies did not show significant differences between the groups. The gene expression of CCR5 and SDF1 was not different between the profiles of AIDS progression. There was no significant correlation between the progression markers (CD4+ TL/CD8+ TL and VL) and the CCR5∆32 polymorphism carrier status. 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subjects Acquired immune deficiency syndrome
AIDS
Alleles
Biomarkers
CCR5 protein
CD4 antigen
CD8 antigen
Chemokines
Controllers
Development and progression
Enzymes
Gene deletion
Gene expression
Gene frequency
Gene polymorphism
Genes
Genetic aspects
Genetic polymorphisms
HIV
HIV (Viruses)
Human immunodeficiency virus
Infections
Lymphocytes
Lymphocytes T
Mutation
Phenotypes
Polymorphism
Restriction fragment length polymorphism
SDF-1 protein
Statistical significance
T cells
Viremia
Virus diseases
title CCR5∆32 and SDF1 3′A: Gene Variants, Expression and Influence on Biological Markers for the Clinical Progression to AIDS among HIV-1 Virus Controllers in a Mixed Population of the Amazon Region of Brazil
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