Aquaporin 5 maintains lens transparency by regulating the lysosomal pathway using circRNA

The lens is transparent, non‐vascular, elastic and wrapped in a transparent capsule. The lens oppacity of AQP5−/− mice was increased more than that of wild‐type (AQP5+/+) mice. In this study, we explored the potential functional role of circular RNAs (circRNAs) and transcription factor HSF4 in lens...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2023-03, Vol.27 (6), p.803-818
Hauptverfasser:	Shaohua, Hu, Yihui, Wang, Kaier, Zhang, Ying, Bai, Xiaoyi, Wang, Hui, Zhao, Guohu, Di, Peng, Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Aquaporin 5 Aquaporin 5 - genetics Aquaporin 5 - metabolism Aquaporins Autophagy Bioinformatics Cataracts circRNA Enzymes Epithelial cells HSF4 Immunoprecipitation lens opacity Lens, Crystalline - metabolism Lysosomes Mice MicroRNAs MicroRNAs - genetics miRNA mRNA Mutation Next-generation sequencing Original Proteins RNA, Circular - metabolism RNA, Messenger - metabolism Software Transmission electron microscopy
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