The Role of Alpha-Synuclein Deposits in Parkinson's Disease: A Focus on the Human Retina

Parkinson's disease (PD) is a neurodegenerative condition characterized by the progressive deterioration of dopaminergic neurons in the central and peripheral autonomous system and the intraneuronal cytoplasmic accumulation of misfolded α-synuclein. The clinical features are the classic triad o...

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Veröffentlicht in:	International journal of molecular sciences 2023-02, Vol.24 (5), p.4391
Hauptverfasser:	Di Pippo, Mariachiara, Fragiotta, Serena, Di Staso, Federico, Scuderi, Luca, Abdolrahimzadeh, Solmaz
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation alpha-Synuclein - metabolism Alzheimer's disease Animal models Animals Brain - metabolism Brain research Dementia Diabetic retinopathy Dopamine Dopamine receptors Humans In vivo methods and tests Metabolism Nervous system Neuropathology Optical Coherence Tomography Parkinson Disease - pathology Parkinson's disease Photoreceptors Proteins Retina Retina - metabolism Review Sensorimotor integration Signs and symptoms Synuclein Tomography Tremor - pathology
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