MRI Characteristics of Pediatric and Young-Adult Renal Cell Carcinoma: A Single-Center Retrospective Study and Literature Review
Pediatric renal cell carcinoma (RCC) is a rare malignancy. Magnetic resonance imaging (MRI) is the preferred imaging modality for assessment of these tumors. The previous literature has suggested that cross-sectional-imaging findings differ between RCC and other pediatric renal tumors and between RC...
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| Veröffentlicht in: | Cancers 2023-02, Vol.15 (5), p.1401 |
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| description | Pediatric renal cell carcinoma (RCC) is a rare malignancy. Magnetic resonance imaging (MRI) is the preferred imaging modality for assessment of these tumors. The previous literature has suggested that cross-sectional-imaging findings differ between RCC and other pediatric renal tumors and between RCC subtypes. However, studies focusing on MRI characteristics are limited. Therefore, this study aims to identify MRI characteristics of pediatric and young-adult RCC, through a single-center case series and literature review. Six identified diagnostic MRI scans were retrospectively assessed, and an extensive literature review was conducted. The included patients had a median age of 12 years (63-193 months). Among other subtypes, 2/6 (33%) were translocation-type RCC (MiT-RCC) and 2/6 (33%) were clear-cell RCC. Median tumor volume was 393 cm
(29-2191 cm
). Five tumors had a hypo-intense appearance on T2-weighted imaging, whereas 4/6 were iso-intense on T1-weighted imaging. Four/six tumors showed well-defined margins. The median apparent diffusion coefficient (ADC) values ranged from 0.70 to 1.20 × 10
mm
/s. In thirteen identified articles focusing on MRI characteristics of MiT-RCC, the majority of the patients also showed T2-weighted hypo-intensity. T1-weighted hyper-intensity, irregular growth pattern and limited diffusion-restriction were also often described. Discrimination of RCC subtypes and differentiation from other pediatric renal tumors based on MRI remains difficult. Nevertheless, T2-weighted hypo-intensity of the tumor seems a potential distinctive characteristic. |
| doi_str_mv | 10.3390/cancers15051401 |
| format | Article |
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(29-2191 cm
). Five tumors had a hypo-intense appearance on T2-weighted imaging, whereas 4/6 were iso-intense on T1-weighted imaging. Four/six tumors showed well-defined margins. The median apparent diffusion coefficient (ADC) values ranged from 0.70 to 1.20 × 10
mm
/s. In thirteen identified articles focusing on MRI characteristics of MiT-RCC, the majority of the patients also showed T2-weighted hypo-intensity. T1-weighted hyper-intensity, irregular growth pattern and limited diffusion-restriction were also often described. Discrimination of RCC subtypes and differentiation from other pediatric renal tumors based on MRI remains difficult. Nevertheless, T2-weighted hypo-intensity of the tumor seems a potential distinctive characteristic.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers15051401</identifier><identifier>PMID: 36900194</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adults ; Biopsy ; Carcinoma, Renal cell ; Case reports ; Chemotherapy ; Children ; Computed tomography ; Demographic aspects ; Diagnosis ; Diffusion coefficient ; Evaluation ; Growth patterns ; Health aspects ; Histopathology ; Kidney cancer ; Literature reviews ; Magnetic resonance imaging ; Malignancy ; Methods ; Patients ; Pediatrics ; Renal cell carcinoma ; Review ; Teenagers ; Tumors</subject><ispartof>Cancers, 2023-02, Vol.15 (5), p.1401</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-e509f173fb0790d2911e806847eaa5f9fd261d70a22ca936439cbff207756a243</citedby><cites>FETCH-LOGICAL-c489t-e509f173fb0790d2911e806847eaa5f9fd261d70a22ca936439cbff207756a243</cites><orcidid>0000-0001-6871-1296 ; 0000-0002-4798-8787</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000563/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000563/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36900194$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beek, Justine N van der</creatorcontrib><creatorcontrib>Krijger, Ronald R de</creatorcontrib><creatorcontrib>Nievelstein, Rutger A J</creatorcontrib><creatorcontrib>Bex, Axel</creatorcontrib><creatorcontrib>Klijn, Aart J</creatorcontrib><creatorcontrib>Heuvel-Eibrink, Marry M van den</creatorcontrib><creatorcontrib>Littooij, Annemieke S</creatorcontrib><title>MRI Characteristics of Pediatric and Young-Adult Renal Cell Carcinoma: A Single-Center Retrospective Study and Literature Review</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Pediatric renal cell carcinoma (RCC) is a rare malignancy. Magnetic resonance imaging (MRI) is the preferred imaging modality for assessment of these tumors. The previous literature has suggested that cross-sectional-imaging findings differ between RCC and other pediatric renal tumors and between RCC subtypes. However, studies focusing on MRI characteristics are limited. Therefore, this study aims to identify MRI characteristics of pediatric and young-adult RCC, through a single-center case series and literature review. Six identified diagnostic MRI scans were retrospectively assessed, and an extensive literature review was conducted. The included patients had a median age of 12 years (63-193 months). Among other subtypes, 2/6 (33%) were translocation-type RCC (MiT-RCC) and 2/6 (33%) were clear-cell RCC. Median tumor volume was 393 cm
(29-2191 cm
). Five tumors had a hypo-intense appearance on T2-weighted imaging, whereas 4/6 were iso-intense on T1-weighted imaging. Four/six tumors showed well-defined margins. The median apparent diffusion coefficient (ADC) values ranged from 0.70 to 1.20 × 10
mm
/s. In thirteen identified articles focusing on MRI characteristics of MiT-RCC, the majority of the patients also showed T2-weighted hypo-intensity. T1-weighted hyper-intensity, irregular growth pattern and limited diffusion-restriction were also often described. Discrimination of RCC subtypes and differentiation from other pediatric renal tumors based on MRI remains difficult. Nevertheless, T2-weighted hypo-intensity of the tumor seems a potential distinctive characteristic.</description><subject>Adults</subject><subject>Biopsy</subject><subject>Carcinoma, Renal cell</subject><subject>Case reports</subject><subject>Chemotherapy</subject><subject>Children</subject><subject>Computed tomography</subject><subject>Demographic aspects</subject><subject>Diagnosis</subject><subject>Diffusion coefficient</subject><subject>Evaluation</subject><subject>Growth patterns</subject><subject>Health aspects</subject><subject>Histopathology</subject><subject>Kidney cancer</subject><subject>Literature reviews</subject><subject>Magnetic resonance imaging</subject><subject>Malignancy</subject><subject>Methods</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Renal cell carcinoma</subject><subject>Review</subject><subject>Teenagers</subject><subject>Tumors</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptksFvFCEUxidGY5vaszdD4sXLtDAMMHgxm4nWJms0rR48EZZ5bGlmYAVmTW_-6WXbWttGSIDA733wPl5VvSb4iFKJj432BmIiDDPSYvKs2m-waGrOZfv8wXqvOkzpEpdGKRFcvKz2KJcYE9nuV3--nJ2i_kJHbTJEl7IzCQWLvsHgdI7OIO0H9DPMfl0vhnnM6Ay8HlEPYxl0NM6HSb9HC3Tu_HqEugdfhAqVY0gbMNltAZ3nebi6UVq6cqrzHKEgWwe_X1UvrB4THN7NB9WPTx-_95_r5deT036xrE3byVwDw9ISQe0KC4mHRhICHeZdK0BrZqUdGk4GgXXTGC0pb6k0K2uLCYJx3bT0oPpwq7uZVxMMpjwz6lFtopt0vFJBO_X4xLsLtQ5bRXbOMU6Lwrs7hRh-zZCymlwyxQftIcxJNaLjBW4ZLujbJ-hlmGPx7YZiRHRCdv-otR5BOW9DudjsRNVCtCVZKRkr1NF_qNIHmJwJHqwr-48Cjm8DTPmBFMHeJ0mw2hWOelI4JeLNQ2_u-b9lQq8Bfwu-nQ</recordid><startdate>20230222</startdate><enddate>20230222</enddate><creator>Beek, Justine N van der</creator><creator>Krijger, Ronald R de</creator><creator>Nievelstein, Rutger A J</creator><creator>Bex, Axel</creator><creator>Klijn, Aart J</creator><creator>Heuvel-Eibrink, Marry M van den</creator><creator>Littooij, Annemieke S</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6871-1296</orcidid><orcidid>https://orcid.org/0000-0002-4798-8787</orcidid></search><sort><creationdate>20230222</creationdate><title>MRI Characteristics of Pediatric and Young-Adult Renal Cell Carcinoma: A Single-Center Retrospective Study and Literature Review</title><author>Beek, Justine N van der ; 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Magnetic resonance imaging (MRI) is the preferred imaging modality for assessment of these tumors. The previous literature has suggested that cross-sectional-imaging findings differ between RCC and other pediatric renal tumors and between RCC subtypes. However, studies focusing on MRI characteristics are limited. Therefore, this study aims to identify MRI characteristics of pediatric and young-adult RCC, through a single-center case series and literature review. Six identified diagnostic MRI scans were retrospectively assessed, and an extensive literature review was conducted. The included patients had a median age of 12 years (63-193 months). Among other subtypes, 2/6 (33%) were translocation-type RCC (MiT-RCC) and 2/6 (33%) were clear-cell RCC. Median tumor volume was 393 cm
(29-2191 cm
). Five tumors had a hypo-intense appearance on T2-weighted imaging, whereas 4/6 were iso-intense on T1-weighted imaging. Four/six tumors showed well-defined margins. The median apparent diffusion coefficient (ADC) values ranged from 0.70 to 1.20 × 10
mm
/s. In thirteen identified articles focusing on MRI characteristics of MiT-RCC, the majority of the patients also showed T2-weighted hypo-intensity. T1-weighted hyper-intensity, irregular growth pattern and limited diffusion-restriction were also often described. Discrimination of RCC subtypes and differentiation from other pediatric renal tumors based on MRI remains difficult. Nevertheless, T2-weighted hypo-intensity of the tumor seems a potential distinctive characteristic.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36900194</pmid><doi>10.3390/cancers15051401</doi><orcidid>https://orcid.org/0000-0001-6871-1296</orcidid><orcidid>https://orcid.org/0000-0002-4798-8787</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adults Biopsy Carcinoma, Renal cell Case reports Chemotherapy Children Computed tomography Demographic aspects Diagnosis Diffusion coefficient Evaluation Growth patterns Health aspects Histopathology Kidney cancer Literature reviews Magnetic resonance imaging Malignancy Methods Patients Pediatrics Renal cell carcinoma Review Teenagers Tumors |
| title | MRI Characteristics of Pediatric and Young-Adult Renal Cell Carcinoma: A Single-Center Retrospective Study and Literature Review |
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