Immunization with Human Immunodeficiency Virus Type 1 rgp120W61D in QS21/MPL Adjuvant Primes T Cell Proliferation and C-C Chemokine Production to Multiple Epitopes within Variable and Conserved Domains of gp120W61D

Human immunodeficiency virus type 1 (HIV-1) gp120W61D—specific T cell lines (TCL) were generated from an HIV-1—seronegative volunteer who received rgp120W61D in QS21/MPL adjuvant with emulsion. TCL were challenged with pools of consecutive, overlapping peptides spanning the gp120W61D sequence and th...

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Veröffentlicht in:	The Journal of infectious diseases 1999-03, Vol.179 (3), p.558-566
Hauptverfasser:	Jones, Gareth J., von Hoegen, Paul, Weber, Jonathan, Rees, Ann D.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Vaccines Amino Acid Sequence Amino Acid Substitution Biological and medical sciences CD4-Positive T-Lymphocytes Cell Line Chemokines, CC - biosynthesis Chemokines, CC - genetics Conserved Sequence Epitopes - chemistry Epitopes - immunology Fundamental and applied biological sciences. Psychology HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - immunology HIV-1 - immunology Humans Lymphocyte Activation Microbiology Molecular Sequence Data Mutagenesis, Site-Directed Protein Structure, Secondary Recombinant Proteins - chemistry Recombinant Proteins - immunology T-Lymphocytes - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic Virology
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