Importance of Conserved Cysteines in the Extracellular Loops of Human PACAP/VIP1 Receptor for Ligand Binding and Stimulation of cAMP Production

The importance of two highly conserved cysteines in the human pituitary adenylate cyclase activating polypeptide (PACAP)/vasoactive intestinal peptide 1 (VIP1) receptor was examined. Using site-directed mutagenesis, each Cys residue was converted into Ala or Ser. The mutant and wildtype genes were t...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 1998-12, Vol.865 (1), p.259-265
Hauptverfasser:	KNUDSEN, SANNE MØLLER, TAMS, JEPPE WEGENER, WULFF, BIRGITTE S., FAHRENKRUG, JAN
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Amino Acid Substitution Binding, Competitive Cell Line Cell Membrane - metabolism Conserved Sequence Cyclic AMP - metabolism Cysteine Humans Models, Molecular Mutagenesis, Site-Directed Protein Structure, Secondary Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide Receptors, Pituitary Hormone - chemistry Receptors, Pituitary Hormone - physiology Receptors, Vasoactive Intestinal Peptide - chemistry Receptors, Vasoactive Intestinal Peptide - physiology Receptors, Vasoactive Intestinal Polypeptide, Type I Recombinant Proteins - chemistry Recombinant Proteins - metabolism Serine Transfection Vasoactive Intestinal Peptide - metabolism Vasoactive Intestinal Peptide - pharmacology
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