Taxol selectively blocks microtubule dependent NF-kappaB activation by phorbol ester via inhibition of IkappaBalpha phosphorylation and degradation

Activation of the NF-kappa-B transcription factors has been shown to be directly influenced by changes in the microtubule cytoskeleton network. To better understand cytoskeletal regulation of NF-kappaB, experiments were performed to determine whether the microtubule (MT) stabilizing agent taxol coul...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 1999-01, Vol.18 (2), p.495
Hauptverfasser:	Spencer, W, Kwon, H, Crépieux, P, Leclerc, N, Lin, R, Hiscott, J
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Base Sequence Biopolymers Cell Line COS Cells DNA Primers DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism Enzyme Activation Fluorescent Antibody Technique, Indirect Humans Hydrolysis I-kappa B Proteins Mice Microtubules - drug effects Microtubules - enzymology Microtubules - metabolism NF-kappa B - metabolism NF-KappaB Inhibitor alpha Paclitaxel - pharmacology Phosphorylation Protein Kinase C - metabolism Tetradecanoylphorbol Acetate - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!