Lack of Evidence for a Polymorphism at Codon 160 of Human O6-Alkylguanine-DNA Alkyltransferase Gene in Normal Tissue and Cancer

O 6 -benzylguanine (BG) is a potent, specific inactivator of the DNA repair protein O 6 -alkylguanine-DNA alkyltransferase (AGT), which enhances sensitivity to nitrosoureas in cells and tumor-bearing animals. BG is presently undergoing clinical trials for development as an agent to enhance the thera...

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Veröffentlicht in:	Clinical cancer research 1999-01, Vol.5 (1), p.209-213
Hauptverfasser:	WU, M. H, LOHRBACH, K. E, OLOPADE, O. I, KOKKINAKIS, D. M, FRIEDMAN, H. S, DOLAN, M. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Biological and medical sciences Cattle Codon Drug Resistance, Neoplasm Drug Screening Assays, Antitumor Guanine - analogs & derivatives Guanine - pharmacology Host-tumor relations. Immunology. Biological markers Humans Medical sciences Mutation Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - genetics O-Methylguanine-DNA Methyltransferase - antagonists & inhibitors O-Methylguanine-DNA Methyltransferase - genetics Polymerase Chain Reaction Polymorphism, Genetic Tumors
Online-Zugang:	Volltext
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