SINGLE DOSE INTRAVENOUS TOXICITY STUDIES OF T-3762, A NOVEL PARENTERAL QUINOLONE ANTIMICROBIAL AGENT, IN RATS, DOGS AND MONKEYS

Single dose intravenous toxicity studies of T-3762, a novel parenteral quinolone antimicrobial agent, were conducted in rats, dogs and monkeys. The following results were obtained. 1. In the rat study, all males and females given 260 mg/kg survived and all males and 3 of 5 females given 391 mg/kg di...

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Veröffentlicht in:	Japanese journal of antibiotics 1998/10/25, Vol.51(10), pp.583-599
Hauptverfasser:	NAGAI, AKIO, SHIBATA, TETSUO, NAGASAWA, MINEKO, SHIOTANI, NORIO, MIYAZAKI, MIYONO, KAWAMURA, YASUHITO, KODAMA, TAKUYA, ONIMARU, TOSHIO
Format:	Artikel
Sprache:	jpn
Schlagworte:	Alanine Transaminase - blood Animals Anti-Infective Agents - administration & dosage Anti-Infective Agents - toxicity Aspartate Aminotransferases - blood Cartilage, Articular - drug effects Dogs Dose-Response Relationship, Drug Female Fluoroquinolones Injections, Intravenous Kidney - drug effects Lethal Dose 50 Liver - drug effects Macaca fascicularis Male Motor Activity - drug effects Mouth Mucosa - drug effects Rats Rats, Sprague-Dawley Respiration - drug effects Respiratory System - drug effects
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