Species Differences in the Biotransformation of 4-(2-Methyl-3-(4-chlorobenzoyl)phenyl)butanoic Acid (RU16029)

1. 4-(2-Methyl-3-(4-chlorobenzoyl)phenyl)butanoic acid (RU 16029) is a potent anti-inflammatory and analgesic agent. In humans, its ketone group is rapidly reduced to an alcohol, whereas in rats, mice and dogs, its butanoic sidechain is rapidly oxidized to the corresponding acetic acid. 2. The exten...

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