CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ alpha beta T cell pool

It is generally accepted that TCR alphabeta+ CD8+ T cells recognize immunogenic peptides bound to MHC-encoded class I molecules. This recognition is a major component of the cellular response mediating immune protection and recovery from viral infections and from certain intracellular bacterial infe...

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Veröffentlicht in:	The Journal of immunology (1950) 1999-01, Vol.162 (1), p.366
Hauptverfasser:	Rosat, J P, Grant, E P, Beckman, E M, Dascher, C C, Sieling, P A, Frederique, D, Modlin, R L, Porcelli, S A, Furlong, S T, Brenner, M B
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Blocking - pharmacology Antibodies, Monoclonal - pharmacology Antigens, Bacterial - immunology Antigens, CD1 - physiology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Line Chromatography, Gel Cytokines - biosynthesis Cytotoxicity Tests, Immunologic Epitopes, T-Lymphocyte - immunology Glycolipids - immunology Glycolipids - isolation & purification Humans Lipids - immunology Lipids - isolation & purification Lymphocyte Activation Mycobacterium tuberculosis - immunology Phospholipids - immunology Phospholipids - isolation & purification Receptors, Antigen, T-Cell, alpha-beta - immunology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism
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