Genetic association of a GABA(A) receptor gamma2 subunit variant with severity of acute physiological dependence on alcohol

The ultimate goal of quantitative trait locus (QTL) mapping is to identify the genes affecting complex traits. Using animal models, we recently identified QTLs on mouse Chromosomes (Chrs) 1, 4, and 11 affecting genetic predisposition to acute alcohol withdrawal. Among mice derived from the C57BL/6J...

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Veröffentlicht in:	Mammalian genome 1998-12, Vol.9 (12), p.975
Hauptverfasser:	Buck, K J, Hood, H M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Central Nervous System Depressants - adverse effects Chromosomes - genetics DNA, Complementary - chemistry DNA, Complementary - genetics Ethanol - adverse effects Female Genetic Predisposition to Disease Genetic Variation Male Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Inbred Strains Polymorphism, Genetic Pregnancy Quantitative Trait, Heritable Receptors, GABA-A - genetics Recombination, Genetic Species Specificity Substance Withdrawal Syndrome - genetics
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