Pharmacokinetic-pharmacodynamic relationships between pirarubicin exposure and hematotoxicity: clinical application using only one blood sample

The objective of the present study was to evaluate the relationship between the pharmacokinetic parameters of pirarubicin and of its metabolite doxorubicin measured in plasma and whole blood, and the hematologic toxicity of this drug, in order to evaluate the predictability of changes in white blood...

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Veröffentlicht in:	Anti-cancer drugs 1998-07, Vol.9 (6), p.503
Hauptverfasser:	Leca, F R, Marchiset-Leca, D, Galeani, A, Noble, A, Catalin, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - blood Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Area Under Curve Doxorubicin - adverse effects Doxorubicin - analogs & derivatives Doxorubicin - blood Doxorubicin - pharmacokinetics Female Humans Leukocyte Count - drug effects Leukopenia - chemically induced Male Middle Aged Neoplasms - blood Neoplasms - drug therapy
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