Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCalpha-inhibitory activity

In a continuation of our search for potential tumor inhibitors from plants, it was found that the CH2Cl2-MeOH (1:1) extracts from Digitalis purpurea and Penstemon linarioides both showed PKCalpha-inhibitory bioactivity. Bioassay-directed fractionation of the extract from D. purpurea yielded the new,...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1998-11, Vol.61 (11), p.1410-1412
Hauptverfasser:	Zhou, B.N, Bahler, B.D, Hofmann, G.A, Mattern, M.R, Johnson, R.K, Kingston, D.G.I
Format:	Artikel
Sprache:	eng
Schlagworte:	antineoplastic agents Caffeic Acids - isolation & purification Caffeic Acids - pharmacology chemical constituents of plants chemical structure Digitalis - chemistry Digitalis purpurea enzyme inhibitors Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology fruits glycosides Glycosides - isolation & purification Glycosides - pharmacology Humans Isoenzymes - antagonists & inhibitors leaves Magnetic Resonance Spectroscopy medicinal plants Penstemon Plants, Medicinal - chemistry Plants, Toxic Protein Kinase C - antagonists & inhibitors Protein Kinase C-alpha spectral analysis Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry, Infrared Spectrophotometry, Ultraviolet stems
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