Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity

In this work, we demonstrate a protective effect conferred by the human multidrug resistance gene (MDR1) to populations of the murine hematopoietic system against the toxic effects of bisantrene, a novel intercalating cytotoxic agent under investigation as an anticancer agent. In vitro, MDR1-express...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 1996-06, Vol.2 (6), p.973-980
Hauptverfasser:	AKSENTIJEVICH, I, CARDARELLI, C. O, PASTAN, I, GOTTESMAN, M. M
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Anthracenes - toxicity Antibiotics, Antineoplastic - toxicity ATP-Binding Cassette, Sub-Family B, Member 1 - genetics B-Lymphocytes - drug effects Biological and medical sciences Dose-Response Relationship, Drug Drug Resistance, Neoplasm Drug toxicity and drugs side effects treatment Gene Transfer Techniques Humans Leukocytes - drug effects Leukopenia - chemically induced Macrophages - drug effects Medical sciences Mice Mice, Inbred C57BL Pharmacology. Drug treatments Retroviridae - genetics Toxicity: blood
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!