Clinical and immunological effects of granulocyte-macrophage colony-stimulating factor coadministered with interleukin 2: a phase IB study

Interleukin 2 (IL-2) and granulocytes-macrophage colony-stimulating factor (GM-CSF) are activators of the lymphocyte and granulocyte/macrophage series, respectively. We conducted a phase IB trial to identify the maximally tolerated dose and to assess immunological effects of the combination. Thirty-...

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Veröffentlicht in:	Clinical cancer research 1996-02, Vol.2 (2), p.319-330
Hauptverfasser:	Schiller, J H, Hank, J A, Khorsand, M, Storer, B, Borchert, A, Huseby-Moore, K, Burns, D, Wesly, O, Albertini, M R, Wilding, G, Sondel, P M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibody-Dependent Cell Cytotoxicity Antineoplastic agents Biological and medical sciences CD56 Antigen - analysis Female Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage Granulocyte-Macrophage Colony-Stimulating Factor - adverse effects HLA-DR Antigens - analysis Humans Immunotherapy Interleukin-2 - administration & dosage Interleukin-2 - adverse effects Killer Cells, Lymphokine-Activated - immunology Male Medical sciences Middle Aged Neoplasms - immunology Neoplasms - therapy Pharmacology. Drug treatments Receptors, IgG - analysis Receptors, Interleukin-2 - analysis
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