Characterization of B1(Fv)PE38 and B1(dsFv)PE38: single-chain and disulfide-stabilized Fv immunotoxins with increased activity that cause complete remissions of established human carcinoma xenografts in nude mice

The mAb B1 (mouse IgG1 kappa) recognizes a carbohydrate epitope on human carcinoma cells (I. Pastan et al., Cancer Res., 51: 3781-3787, 1991). We have generated plasmids encoding immunotoxins in which the Fv domain of B1, either as a single-chain Fv or as a disulfide-stabilized Fv (dsFv), was fused...

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Veröffentlicht in:	Clinical cancer research 1995-09, Vol.1 (9), p.1023-1029
Hauptverfasser:	BENHAR, I, PASTAN, I
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP Ribose Transferases Animals Antibodies, Monoclonal - therapeutic use Antineoplastic agents Bacterial Toxins Biological and medical sciences Drug Screening Assays, Antitumor Exotoxins - chemistry Exotoxins - immunology Exotoxins - pharmacokinetics Exotoxins - therapeutic use Humans Immunoglobulin Variable Region Immunotherapy Immunotoxins - chemistry Immunotoxins - immunology Immunotoxins - pharmacokinetics Immunotoxins - therapeutic use Medical sciences Mice Mice, Nude Pharmacology. Drug treatments Pseudomonas aeruginosa Exotoxin A Remission Induction Transplantation, Heterologous Virulence Factors
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