A phase I and pharmacokinetic study of a new camptothecin derivative, 9-aminocamptothecin

Camptothecins are the only available antitumor agents which target the nuclear enzyme topoisomerase I. 9-Aminocamptothecin (9-AC) is a water-insoluble derivative of camptothecin which has demonstrated impressive antitumor activity in preclinical models. While two other water-soluble derivatives, CPT...

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Veröffentlicht in:	Clinical cancer research 1995-03, Vol.1 (3), p.269-276
Hauptverfasser:	RUBIN, E, WOOD, V, KUFE, D, BHARTI, A, TRITES, D, LYNCH, C, HURWITZ, S, BARTEL, S, LEVY, S, ROSOWSKY, A, TOPPMEYER, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anemia - chemically induced Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacokinetics Biological and medical sciences Camptothecin - administration & dosage Camptothecin - adverse effects Camptothecin - analogs & derivatives Camptothecin - pharmacokinetics Chemotherapy DNA Topoisomerases, Type I - blood DNA Topoisomerases, Type II - blood Drug Administration Schedule Female Half-Life Humans Infusions, Intravenous Leukocytes, Mononuclear - enzymology Male Medical sciences Metabolic Clearance Rate Middle Aged Neoplasms - blood Neoplasms - drug therapy Neutropenia - chemically induced Pharmacology. Drug treatments Thrombocytopenia - chemically induced
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