Pharmacokinetic interrelationships of irinotecan (CPT-11) and its three major plasma metabolites in patients enrolled in phase I/II trials

Irinotecan (CPT-11) is an analogue of 20(S)-camptothecin with promising activity against several tumor types. In patients, CPT-11 is metabolized to 7-ethyl-10-hydroxycamptothecin (SN-38) and to the beta-glucuronide of SN-38. Recently, we identified an additional metabolite of CPT-11, 7-ethyl-10-[4-N...

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Veröffentlicht in:	Clinical cancer research 1997-08, Vol.3 (8), p.1261-1266
Hauptverfasser:	RIVORY, L. P, HAAZ, M.-C, CANAL, P, LOKIEC, F, ARMAND, J.-P, ROBERT, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents, Phytogenic - blood Antineoplastic Agents, Phytogenic - pharmacokinetics Antineoplastic Agents, Phytogenic - therapeutic use Biological and medical sciences Biotransformation Camptothecin - adverse effects Camptothecin - analogs & derivatives Camptothecin - blood Camptothecin - pharmacokinetics Camptothecin - therapeutic use Chemotherapy France Glucuronates - blood Humans Medical sciences Metabolic Clearance Rate Models, Biological Neoplasms - blood Neoplasms - drug therapy Pharmacology. Drug treatments
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