Flavopiridol (L86-8275): selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells

We have selected a panel of human tumor xenografts for in vitro and in vivo studies that allows an indication of selectivity of action of novel chemotherapeutic agents. We report here the antitumor activity of the flavone flavopiridol (previously designated L86-8275), which has been selected for fur...

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Veröffentlicht in:	Clinical cancer research 1997-02, Vol.3 (2), p.273-279
Hauptverfasser:	DREES, M, DENGLER, W. A, ROTH, T, LABONTE, H, MAYO, J, MALSPEIS, L, GREVER, M, SAUSVILLE, E. A, FIEBIG, H. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biological and medical sciences Chemotherapy Colony-Forming Units Assay Drug Screening Assays, Antitumor Flavonoids - pharmacology Flavonoids - therapeutic use Humans Male Medical sciences Mice Mice, Nude Neoplasm Transplantation Pharmacology. Drug treatments Piperidines - pharmacology Piperidines - therapeutic use Prostatic Neoplasms - drug therapy Tumor Cells, Cultured
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