Phase I and pharmacokinetic study of tirapazamine (SR 4233) administered every three weeks

Tirapazamine (SR 4233; 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide) is a bioreductive agent exhibiting up to 200 x greater toxicity for hypoxic cells as compared to oxygenated cells. In murine studies, a selective increase in tumor kill was observed when tirapazamine was coadministered with other age...

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Veröffentlicht in:	Clinical cancer research 1997-01, Vol.3 (1), p.31-38
Hauptverfasser:	S Senan, R Rampling, M A Graham, P Wilson, H Robin, Jr, N Eckardt, N Lawson, A McDonald, R von Roemeling, P Workman, S B Kaye
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacokinetics Biological and medical sciences Chemotherapy Drug Administration Schedule Female Humans Male Medical sciences Middle Aged Muscle Cramp - chemically induced Nausea - chemically induced Neoplasms - drug therapy Neoplasms - metabolism Pharmacology. Drug treatments Thrombocytopenia - chemically induced Triazines - adverse effects Triazines - pharmacokinetics Vomiting - chemically induced
Online-Zugang:	Volltext
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