Defective proximal tubule lysosomal acidification by Bence Jones proteins: An immunoelectron microscopy study

Proximal tubule handling of two human Bence Jones proteins (neutral and acidic BJP) was evaluated using protein A-gold labelling. After 30 min of acute light-chain infusion into 6 rats (alone or in combination with dinitrophenyl-aminopropyl-methylamine [DAMP]), kidney biopsies were processed for imm...

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Veröffentlicht in:	Experimental nephrology 1998-11, Vol.6 (6), p.514-521
Hauptverfasser:	NICASTRI, A. L, BRANDAO DE ALMEIDA PRADO, M. J, SESSO, A, BRANDAO DE ALMEIDA PRADO, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids - metabolism Animals Bence Jones Protein - chemistry Bence Jones Protein - metabolism Biological and medical sciences Blotting, Western Dinitrobenzenes - pharmacokinetics Electrophoresis, Polyacrylamide Gel Hematologic and hematopoietic diseases Humans Hydrogen-Ion Concentration Kidney Tubules, Proximal - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lysosomes - metabolism Male Medical sciences Microscopy, Immunoelectron Rats Rats, Wistar Receptor, IGF Type 2 - metabolism
Online-Zugang:	Volltext
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