[31] Dopamine transporter mutants, small molecules, and approaches to cocaine antagonist/dopamine transporter disinhibitor development

Dopamine transporters (DAT) terminate dopaminergic neurotransmission by Na+ and Cl− dependent reaccumulation of dopamine into presynaptic neurons. A number of substantial lines of evidence have suggested that the actions of cocaine in inducing its rewarding and reinforcing properties are largely bec...

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