Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes : Selective catalysis by fmo3

In the present study, we expressed human flavin-containing monooxygenase 1 (FMO1), FMO3, FMO4t (truncated), and FMO5 in the baculovirus expression vector system at levels of 0.6 to 2.4 nmol FMO/mg of membrane protein. These four isoforms, as well as purified rabbit FMO2, and eleven heterologously ex...

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Veröffentlicht in:	Biochemical pharmacology 1998-10, Vol.56 (8), p.1005-1012
Hauptverfasser:	Lang, DieterH, Yeung, CatherineK, Peter, RaimundM, Ibarra, Catherine, Gasser, Rodolfo, Itagaki, Kiyoshi, Philpot, RichardM, Rettie, AllanE
Format:	Artikel
Sprache:	eng
Schlagworte:	benzydamine Biological and medical sciences Chromatography, High Pressure Liquid Cytochrome P-450 Enzyme System - metabolism cytochrome P450 flavin-containing monooxygenase Fundamental and applied biological sciences. Psychology Gene expression Humans Intestines - enzymology Kidney - enzymology Kinetics Liver - embryology Liver - enzymology Methylamines - metabolism Microsomes - enzymology Microsomes, Liver - enzymology Molecular and cellular biology Molecular genetics N-oxidation Oxidants - metabolism Oxygenases - metabolism trimethylamine trimethylaminuria
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