Pharmacological Characterization of 6-Bromo-3′-nitroflavone, a Synthetic Flavonoid with High Affinity for the Benzodiazepine Receptors

6-Bromo-3′-nitroflavone is a synthetic flavone derivative that selectively recognizes benzodiazepine receptors and has potent anxiolytic-like effects. Here, we describe in detail its pharmacological characterization. When IP injected in mice, 6-bromo-3′-nitroflavone (0.01–0.3 mg/kg) had an anxiolyti...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1998-11, Vol.61 (3), p.239-246
Hauptverfasser:	Wolfman, C., Viola, H., Marder, M., Ardenghi, P., Wasowski, C., Schröder, N., Izquierdo, I., Rúveda, E., Paladini, A., Medina, J.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonist Animals Anti-Anxiety Agents - pharmacology Anxiety Avoidance Learning - drug effects Avoidance Learning - physiology Benzodiazepine receptors Biological and medical sciences Flavonoids Flavonoids - pharmacology Flavonoids - therapeutic use GABA-A Receptor Agonists Male Maze Learning - drug effects Maze Learning - physiology Medical sciences Mice Motor Activity - drug effects Motor Activity - physiology Neuropharmacology Pentobarbital - pharmacology Pentylenetetrazole - pharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychomotor Performance - drug effects Psychopharmacology Sedation Seizures - chemically induced Seizures - drug therapy Sleep - drug effects Sleep - physiology
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