Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells

Apoptosis mediated by anticancer drugs may involve activation of death-inducing ligand/receptor systems such as CD95 (APO-1/Fas), cleavage of caspases, and perturbance of mitochondrial functions. We investigated the sequence of these events in SHEP neuroblastoma cells transfected with Bcl-2 or Bcl-X...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1998-10, Vol.58 (19), p.4453-4460
Hauptverfasser:	FULDA, S, SUSIN, S. A, KROEMER, G, DEBATIN, K.-M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - toxicity Apoptosis - drug effects bcl-X Protein Biological and medical sciences Chemotherapy Cytosol - drug effects DNA, Neoplasm - metabolism Doxorubicin - toxicity Fas Ligand Protein fas Receptor - genetics Gene Expression Regulation, Neoplastic - drug effects Humans Intracellular Membranes - drug effects Intracellular Membranes - physiology Medical sciences Membrane Glycoproteins - genetics Membrane Potentials - drug effects Mitochondria - drug effects Mitochondria - physiology Models, Biological Neuroblastoma - pathology Neuroblastoma - physiopathology Pharmacology. Drug treatments Proto-Oncogene Proteins c-bcl-2 - genetics Triterpenes - toxicity Tumor Cells, Cultured
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