THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?

Mammalian AMP-activated protein kinase and yeast SNF1 protein kinase are the central components of kinase cascades that are highly conserved between animals, fungi, and plants. The AMP-activated protein kinase cascade acts as a metabolic sensor or "fuel gauge" that monitors cellular AMP an...

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Veröffentlicht in:	Annual review of biochemistry 1998-01, Vol.67 (1), p.821-855
Hauptverfasser:	Hardie, D. Grahame, Carling, David, Carlson, Marian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Monophosphate - metabolism Amino Acid Sequence AMP-Activated Protein Kinases ATP ATP depletion Biosynthesis cellular stress Cloning Enzymes Eukaryotic Cells Fatty acids gene expression Genes Glucose glucose repression Hypotheses Kinases Liver Metabolism Molecular Sequence Data Multienzyme Complexes - genetics Multienzyme Complexes - metabolism Mutation Phosphorylation Physiology Protein Kinases - genetics Protein Kinases - metabolism protein phosphorylation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Saccharomyces cerevisiae Signal Transduction Yeast Yeasts
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