Nitrosation of uric acid by peroxynitrite. Formation of a vasoactive nitric oxide donor

Peroxynitrite (ONOO-), formed by the reaction between nitric oxide (. NO) and superoxide, has been implicated in the etiology of numerous disease processes. Low molecular weight antioxidants, including uric acid, may minimize ONOO---mediated damage to tissues. The tissue-sparing effects of uric acid...

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Veröffentlicht in:	The Journal of biological chemistry 1998-09, Vol.273 (38), p.24491
Hauptverfasser:	Skinner, K A, White, C R, Patel, R, Tan, S, Barnes, S, Kirk, M, Darley-Usmar, V, Parks, D A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic - drug effects Aorta, Thoracic - physiology Chromatography, High Pressure Liquid Electrochemistry Endothelium, Vascular - physiology Humans Imidazoles - chemistry Imidazoles - pharmacology In Vitro Techniques Isometric Contraction - drug effects Kinetics Mass Spectrometry Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Nitrates - chemistry Nitrates - pharmacology Nitric Oxide - chemistry Nitric Oxide - pharmacology Oxidants - chemistry Oxidants - pharmacology Oxyhemoglobins - chemistry Oxyhemoglobins - drug effects Photolysis Rats Spectrophotometry Uric Acid - blood Uric Acid - chemistry Vasodilation
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