Antiviral Treatment of Idiopathic Sudden Sensorineural Hearing Loss: A Prospective, Randomized, Double-blind Clinical Trial
A subclinical viral labyrinthitis has been postulated in the literature to elicit Idiopathic Sudden Sensorineural Hearing Loss. An etiological role for the herpes virus family is assumed. Corticosteroids possess a limited beneficial effect on hearing recovery in ISSHL. In this study, the therapeutic...
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| Veröffentlicht in: | Acta oto-laryngologica 1998-07, Vol.118 (4), p.488-495 |
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| creator | STOKROOS, R. J ALBERS, F. W. J TENVERGERT, E. M |
| description | A subclinical viral labyrinthitis has been postulated in the literature to elicit Idiopathic Sudden Sensorineural Hearing Loss. An etiological role for the herpes virus family is assumed. Corticosteroids possess a limited beneficial effect on hearing recovery in ISSHL. In this study, the therapeutic value of the antiherpetic drug aciclovir (Zovirax®) on hearing recovery in 44 ISSHL patients receiving prednisolone is evaluated in a multicentre clinical trial. The study is designed prospectively, randomized, double-blind and placebo-controlled. Subjective parameters include hearing recovery, a pressure sensation on the affected ear, disequilibrium or vertigo and tinnitus. Audiometric parameters include pure tone and speech audiometry. A one-year follow up is obtained. Both the pressure sensation and disequilibrium or vertigo have a good prognosis, but tinnitus, occurring in most patients, has a poor prognosis. Hearing recovery prognosis depends on the severity of initial hearing loss, and not on vestibular involvement. No beneficial effect from combining aciclovir with prednisolone can be established in ISSHL. |
| doi_str_mv | 10.1080/00016489850154603 |
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Both the pressure sensation and disequilibrium or vertigo have a good prognosis, but tinnitus, occurring in most patients, has a poor prognosis. Hearing recovery prognosis depends on the severity of initial hearing loss, and not on vestibular involvement. No beneficial effect from combining aciclovir with prednisolone can be established in ISSHL.</description><identifier>ISSN: 0001-6489</identifier><identifier>EISSN: 1651-2251</identifier><identifier>DOI: 10.1080/00016489850154603</identifier><identifier>PMID: 9726671</identifier><identifier>CODEN: AOLAAJ</identifier><language>eng</language><publisher>Stockholm: Informa UK Ltd</publisher><subject>Acyclovir - therapeutic use ; Anti-Inflammatory Agents - therapeutic use ; Antiviral Agents - therapeutic use ; Audiometry ; Biological and medical sciences ; Double-Blind Method ; Drug Therapy, Combination ; Ent. Stomatology ; Female ; Hearing Loss, Sensorineural - drug therapy ; Hearing Loss, Sensorineural - virology ; Herpes Simplex - complications ; Herpes Simplex - drug therapy ; Herpesvirus ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. 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J</creatorcontrib><creatorcontrib>ALBERS, F. W. J</creatorcontrib><creatorcontrib>TENVERGERT, E. M</creatorcontrib><title>Antiviral Treatment of Idiopathic Sudden Sensorineural Hearing Loss: A Prospective, Randomized, Double-blind Clinical Trial</title><title>Acta oto-laryngologica</title><addtitle>Acta Otolaryngol</addtitle><description>A subclinical viral labyrinthitis has been postulated in the literature to elicit Idiopathic Sudden Sensorineural Hearing Loss. An etiological role for the herpes virus family is assumed. Corticosteroids possess a limited beneficial effect on hearing recovery in ISSHL. In this study, the therapeutic value of the antiherpetic drug aciclovir (Zovirax®) on hearing recovery in 44 ISSHL patients receiving prednisolone is evaluated in a multicentre clinical trial. The study is designed prospectively, randomized, double-blind and placebo-controlled. Subjective parameters include hearing recovery, a pressure sensation on the affected ear, disequilibrium or vertigo and tinnitus. Audiometric parameters include pure tone and speech audiometry. A one-year follow up is obtained. Both the pressure sensation and disequilibrium or vertigo have a good prognosis, but tinnitus, occurring in most patients, has a poor prognosis. Hearing recovery prognosis depends on the severity of initial hearing loss, and not on vestibular involvement. No beneficial effect from combining aciclovir with prednisolone can be established in ISSHL.</description><subject>Acyclovir - therapeutic use</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Audiometry</subject><subject>Biological and medical sciences</subject><subject>Double-Blind Method</subject><subject>Drug Therapy, Combination</subject><subject>Ent. Stomatology</subject><subject>Female</subject><subject>Hearing Loss, Sensorineural - drug therapy</subject><subject>Hearing Loss, Sensorineural - virology</subject><subject>Herpes Simplex - complications</subject><subject>Herpes Simplex - drug therapy</subject><subject>Herpesvirus</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. 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M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-495cf1ca259654d02a01a797ff59a7228adcb997804345d4ae0e5ab066744fb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acyclovir - therapeutic use</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Audiometry</topic><topic>Biological and medical sciences</topic><topic>Double-Blind Method</topic><topic>Drug Therapy, Combination</topic><topic>Ent. Stomatology</topic><topic>Female</topic><topic>Hearing Loss, Sensorineural - drug therapy</topic><topic>Hearing Loss, Sensorineural - virology</topic><topic>Herpes Simplex - complications</topic><topic>Herpes Simplex - drug therapy</topic><topic>Herpesvirus</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Prednisolone - therapeutic use</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STOKROOS, R. J</creatorcontrib><creatorcontrib>ALBERS, F. W. J</creatorcontrib><creatorcontrib>TENVERGERT, E. 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J</au><au>ALBERS, F. W. J</au><au>TENVERGERT, E. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiviral Treatment of Idiopathic Sudden Sensorineural Hearing Loss: A Prospective, Randomized, Double-blind Clinical Trial</atitle><jtitle>Acta oto-laryngologica</jtitle><addtitle>Acta Otolaryngol</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>118</volume><issue>4</issue><spage>488</spage><epage>495</epage><pages>488-495</pages><issn>0001-6489</issn><eissn>1651-2251</eissn><coden>AOLAAJ</coden><abstract>A subclinical viral labyrinthitis has been postulated in the literature to elicit Idiopathic Sudden Sensorineural Hearing Loss. An etiological role for the herpes virus family is assumed. Corticosteroids possess a limited beneficial effect on hearing recovery in ISSHL. In this study, the therapeutic value of the antiherpetic drug aciclovir (Zovirax®) on hearing recovery in 44 ISSHL patients receiving prednisolone is evaluated in a multicentre clinical trial. The study is designed prospectively, randomized, double-blind and placebo-controlled. Subjective parameters include hearing recovery, a pressure sensation on the affected ear, disequilibrium or vertigo and tinnitus. Audiometric parameters include pure tone and speech audiometry. A one-year follow up is obtained. Both the pressure sensation and disequilibrium or vertigo have a good prognosis, but tinnitus, occurring in most patients, has a poor prognosis. Hearing recovery prognosis depends on the severity of initial hearing loss, and not on vestibular involvement. No beneficial effect from combining aciclovir with prednisolone can be established in ISSHL.</abstract><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>9726671</pmid><doi>10.1080/00016489850154603</doi><tpages>8</tpages></addata></record> |
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| ispartof | Acta oto-laryngologica, 1998-07, Vol.118 (4), p.488-495 |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Acyclovir - therapeutic use Anti-Inflammatory Agents - therapeutic use Antiviral Agents - therapeutic use Audiometry Biological and medical sciences Double-Blind Method Drug Therapy, Combination Ent. Stomatology Female Hearing Loss, Sensorineural - drug therapy Hearing Loss, Sensorineural - virology Herpes Simplex - complications Herpes Simplex - drug therapy Herpesvirus Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Prednisolone - therapeutic use Prognosis Prospective Studies |
| title | Antiviral Treatment of Idiopathic Sudden Sensorineural Hearing Loss: A Prospective, Randomized, Double-blind Clinical Trial |
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