An inactive pancreatic lipase-related protein is activated into a triglyceride-lipase by mutagenesis based on the 3-D structure

Both classical dog pancreatic lipase (DPL) and dog pancreatic lipase-related protein 1 (DPLRP1) have been found to be secreted by the exocrine pancreas. These two proteins were purified to homogeneity from canine pancreatic juice and no significant catalytic activity was observed with DPLRP1 on any...

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Veröffentlicht in:	Chemistry and physics of lipids 1998-06, Vol.93 (1-2), p.103
Hauptverfasser:	Bezzine, S, Roussel, A, de Caro, J, Gastinel, L, de Caro, A, Carrière, F, Leydier, S, Verger, R, Cambillau, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Crystallography, X-Ray Dogs Enzyme Activation Kinetics Lipase - chemistry Lipase - genetics Lipase - isolation & purification Lipase - metabolism Models, Molecular Molecular Sequence Data Mutagenesis Mutation Pancreatic Juice - chemistry Pancreatic Juice - enzymology Protein Conformation Structure-Activity Relationship Triglycerides - metabolism
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