Humanized M195 monoclonal antibody conjugated to recombinant gelonin: an anti-CD33 immunotoxin with antileukemic activity

The recently characterized immunotoxin HuM195-gelonin consists of a humanized anti-CD33 monoclonal antibody conjugated to the single-chain plant toxin gelonin. Binding of the immunotoxin to hematopoietic cells that express the CD33 differentiation antigen has been demonstrated and results in cytotox...

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Veröffentlicht in:	Clinical cancer research 1998-08, Vol.4 (8), p.1971-1976
Hauptverfasser:	PAGLIARO, L. C, LIU, B, MUNKER, R, ANDREEFF, M, FREIREICH, E. J, SCHEINBERG, D. A, ROSENBLUM, M. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antigens, CD - immunology Antigens, Differentiation, Myelomonocytic - immunology Antineoplastic agents Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Bone Marrow Transplantation Cryopreservation Humans Immunotherapy Immunotoxins - pharmacology Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - pathology Medical sciences Pharmacology. Drug treatments Plant Proteins - pharmacology Recombinant Proteins - pharmacology Ribosome Inactivating Proteins, Type 1 Sensitivity and Specificity Sialic Acid Binding Ig-like Lectin 3 Tumor Cells, Cultured
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