Synthesis and Antiviral Evaluation of Pyrazinones Substituted with Acyclic Chains

The synthesis of a series of pyrazine analogues of the anti-herpes compound, acyclovir is described. These syntheses were accomplished by various methods: in the presence of a Lewis acid or NaH for hydroxyethoxymethyl and hydroxybutyl groups or by sequential oxidation/reduction of l-β-D-ribofuranosy...

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Veröffentlicht in:	Nucleosides & nucleotides 1998-05, Vol.17 (5), p.875-892
Hauptverfasser:	Davis, Jean, Benhaddou, Rachida, Granet, Robert, Krausz, Pierre, Demonte, Michele, Aubertin, Anne Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Cell Line Cytomegalovirus - drug effects Drug Design Enterovirus B, Human - drug effects Herpesvirus 1, Human - drug effects Humans Microbial Sensitivity Tests Models, Chemical Pyrazines - chemical synthesis Pyrazines - pharmacology Vaccinia virus - drug effects
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