Local anesthetic efficacy for oral surgery: Comparison of diphenhydramine and prilocaine
Objective. Diphenhydramine has been suggested as an alternative local anesthetic agent for patients claiming allergy to local anesthetics. The present study attempted to determine the local anesthetic efficacy of diphenhydramine for oral surgery. Study design. Seventeen patients claiming allergy to...
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| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 1998-07, Vol.86 (1), p.26-30 |
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| container_title | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics |
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| creator | Uckan, Sina Guler, Nurhan Sumer, Mahmut Ungor, Mete |
| description | Objective.
Diphenhydramine has been suggested as an alternative local anesthetic agent for patients claiming allergy to local anesthetics. The present study attempted to determine the local anesthetic efficacy of diphenhydramine for oral surgery.
Study design.
Seventeen patients claiming allergy to local anesthetics were given diphenhydramine as anesthetic alternative and compared with seven nonallergic control patients treated with prilocaine. After determining an average value of vitality score of neighboring and contralateral teeth by electrical pulp stimulation, molar and premolar teeth were extracted and postextraction vitality scores determined. Visual analogue scale, anesthesia onset times, and the incidence of pulpal and soft tissue anesthesia were analyzed nonparametrically by means of Mann-Whitney
U tests.
Results.
The mean onset time of pulp anesthesia with diphenhydramine (range, 4 to 7.5 minutes), excluding one failure, was not significantly different from that of prilocaine; (range, 4 to 13 minutes). The duration of anesthesia was significantly longer and the visual analogue scale lower in the group receiving prilocaine in comparison with the group receiving diphenhydramine.
Conclusion.
In the small group studied, diphenhydramine administration provided adequate anesthesia before oral surgery; it may be useful as an anesthetic alternative in patients with histories of allergy to local anesthetics. |
| doi_str_mv | 10.1016/S1079-2104(98)90145-7 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_pasca</sourceid><recordid>TN_cdi_pubmed_primary_9690241</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1079210498901457</els_id><sourcerecordid>9690241</sourcerecordid><originalsourceid>FETCH-LOGICAL-e291t-88285880673ace0ccba6feaeb5a7882972cfbb7e40f370d3301b9dcda12bd6d33</originalsourceid><addsrcrecordid>eNo9UEtLAzEYDKLUWv0JhT140MNqHrubxItI8QUFDyr0FrLJFxvp7pZkK-y_N33o6fuGGYaZQWhK8A3BpLp9J5jLnBJcXElxLTEpypwfoTEpqciZLBfH6f-TnKKzGL8xxhWTcoRGspKYFmSMFvPO6FWmW4j9EnpvMnDOG22GzHUh60Ii4yZ8QRjuslnXrHXwsWuzzmXWr5fQLgcbdONbSB42Wwe_SoYJnqMTp1cRLg53gj6fHj9mL_n87fl19jDPgUrS50JQUQqBK860AWxMrSsHGupS88RJTo2raw4FdoxjyxgmtbTGakJrWyU8QdO973pTN2BVStDoMKhDw8RfHngdU1MXdGt8_JdRxrgUVZLd72WQsv54CCoaD60B6wOYXtnOK4LVdnm1W15tZ1VSqN3yirNfS592ZA</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Local anesthetic efficacy for oral surgery: Comparison of diphenhydramine and prilocaine</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Uckan, Sina ; Guler, Nurhan ; Sumer, Mahmut ; Ungor, Mete</creator><creatorcontrib>Uckan, Sina ; Guler, Nurhan ; Sumer, Mahmut ; Ungor, Mete</creatorcontrib><description>Objective.
Diphenhydramine has been suggested as an alternative local anesthetic agent for patients claiming allergy to local anesthetics. The present study attempted to determine the local anesthetic efficacy of diphenhydramine for oral surgery.
Study design.
Seventeen patients claiming allergy to local anesthetics were given diphenhydramine as anesthetic alternative and compared with seven nonallergic control patients treated with prilocaine. After determining an average value of vitality score of neighboring and contralateral teeth by electrical pulp stimulation, molar and premolar teeth were extracted and postextraction vitality scores determined. Visual analogue scale, anesthesia onset times, and the incidence of pulpal and soft tissue anesthesia were analyzed nonparametrically by means of Mann-Whitney
U tests.
Results.
The mean onset time of pulp anesthesia with diphenhydramine (range, 4 to 7.5 minutes), excluding one failure, was not significantly different from that of prilocaine; (range, 4 to 13 minutes). The duration of anesthesia was significantly longer and the visual analogue scale lower in the group receiving prilocaine in comparison with the group receiving diphenhydramine.
Conclusion.
In the small group studied, diphenhydramine administration provided adequate anesthesia before oral surgery; it may be useful as an anesthetic alternative in patients with histories of allergy to local anesthetics.</description><identifier>ISSN: 1079-2104</identifier><identifier>EISSN: 1528-395X</identifier><identifier>DOI: 10.1016/S1079-2104(98)90145-7</identifier><identifier>PMID: 9690241</identifier><language>eng</language><publisher>St. Louis, MO: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Anesthesia ; Anesthesia depending on type of surgery ; Anesthesia, Dental ; Anesthesia, Local ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthetics, Local - administration & dosage ; Anesthetics, Local - adverse effects ; Anesthetics. Neuromuscular blocking agents ; Bicuspid - surgery ; Biological and medical sciences ; Dental Pulp - drug effects ; Dental Pulp - physiology ; Diphenhydramine - administration & dosage ; Drug Hypersensitivity - etiology ; Electric Stimulation ; Female ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; Molar - surgery ; Molar, Third - surgery ; Neuropharmacology ; Orthopedic surgery. Maxillofacial surgery. Otorhinolaryngologic surgery. Stomatology. Ophtalmology. Investigation and treatment technics ; Pain - prevention & control ; Pain Measurement ; Pharmacology. Drug treatments ; Prilocaine - administration & dosage ; Time Factors ; Tooth Extraction</subject><ispartof>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 1998-07, Vol.86 (1), p.26-30</ispartof><rights>1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1079-2104(98)90145-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2337986$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9690241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uckan, Sina</creatorcontrib><creatorcontrib>Guler, Nurhan</creatorcontrib><creatorcontrib>Sumer, Mahmut</creatorcontrib><creatorcontrib>Ungor, Mete</creatorcontrib><title>Local anesthetic efficacy for oral surgery: Comparison of diphenhydramine and prilocaine</title><title>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</title><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><description>Objective.
Diphenhydramine has been suggested as an alternative local anesthetic agent for patients claiming allergy to local anesthetics. The present study attempted to determine the local anesthetic efficacy of diphenhydramine for oral surgery.
Study design.
Seventeen patients claiming allergy to local anesthetics were given diphenhydramine as anesthetic alternative and compared with seven nonallergic control patients treated with prilocaine. After determining an average value of vitality score of neighboring and contralateral teeth by electrical pulp stimulation, molar and premolar teeth were extracted and postextraction vitality scores determined. Visual analogue scale, anesthesia onset times, and the incidence of pulpal and soft tissue anesthesia were analyzed nonparametrically by means of Mann-Whitney
U tests.
Results.
The mean onset time of pulp anesthesia with diphenhydramine (range, 4 to 7.5 minutes), excluding one failure, was not significantly different from that of prilocaine; (range, 4 to 13 minutes). The duration of anesthesia was significantly longer and the visual analogue scale lower in the group receiving prilocaine in comparison with the group receiving diphenhydramine.
Conclusion.
In the small group studied, diphenhydramine administration provided adequate anesthesia before oral surgery; it may be useful as an anesthetic alternative in patients with histories of allergy to local anesthetics.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anesthesia</subject><subject>Anesthesia depending on type of surgery</subject><subject>Anesthesia, Dental</subject><subject>Anesthesia, Local</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Anesthetics, Local - adverse effects</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Bicuspid - surgery</subject><subject>Biological and medical sciences</subject><subject>Dental Pulp - drug effects</subject><subject>Dental Pulp - physiology</subject><subject>Diphenhydramine - administration & dosage</subject><subject>Drug Hypersensitivity - etiology</subject><subject>Electric Stimulation</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molar - surgery</subject><subject>Molar, Third - surgery</subject><subject>Neuropharmacology</subject><subject>Orthopedic surgery. Maxillofacial surgery. Otorhinolaryngologic surgery. Stomatology. Ophtalmology. Investigation and treatment technics</subject><subject>Pain - prevention & control</subject><subject>Pain Measurement</subject><subject>Pharmacology. Drug treatments</subject><subject>Prilocaine - administration & dosage</subject><subject>Time Factors</subject><subject>Tooth Extraction</subject><issn>1079-2104</issn><issn>1528-395X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UEtLAzEYDKLUWv0JhT140MNqHrubxItI8QUFDyr0FrLJFxvp7pZkK-y_N33o6fuGGYaZQWhK8A3BpLp9J5jLnBJcXElxLTEpypwfoTEpqciZLBfH6f-TnKKzGL8xxhWTcoRGspKYFmSMFvPO6FWmW4j9EnpvMnDOG22GzHUh60Ii4yZ8QRjuslnXrHXwsWuzzmXWr5fQLgcbdONbSB42Wwe_SoYJnqMTp1cRLg53gj6fHj9mL_n87fl19jDPgUrS50JQUQqBK860AWxMrSsHGupS88RJTo2raw4FdoxjyxgmtbTGakJrWyU8QdO973pTN2BVStDoMKhDw8RfHngdU1MXdGt8_JdRxrgUVZLd72WQsv54CCoaD60B6wOYXtnOK4LVdnm1W15tZ1VSqN3yirNfS592ZA</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>Uckan, Sina</creator><creator>Guler, Nurhan</creator><creator>Sumer, Mahmut</creator><creator>Ungor, Mete</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19980701</creationdate><title>Local anesthetic efficacy for oral surgery: Comparison of diphenhydramine and prilocaine</title><author>Uckan, Sina ; Guler, Nurhan ; Sumer, Mahmut ; Ungor, Mete</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e291t-88285880673ace0ccba6feaeb5a7882972cfbb7e40f370d3301b9dcda12bd6d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anesthesia</topic><topic>Anesthesia depending on type of surgery</topic><topic>Anesthesia, Dental</topic><topic>Anesthesia, Local</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthetics, Local - administration & dosage</topic><topic>Anesthetics, Local - adverse effects</topic><topic>Anesthetics. Neuromuscular blocking agents</topic><topic>Bicuspid - surgery</topic><topic>Biological and medical sciences</topic><topic>Dental Pulp - drug effects</topic><topic>Dental Pulp - physiology</topic><topic>Diphenhydramine - administration & dosage</topic><topic>Drug Hypersensitivity - etiology</topic><topic>Electric Stimulation</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molar - surgery</topic><topic>Molar, Third - surgery</topic><topic>Neuropharmacology</topic><topic>Orthopedic surgery. Maxillofacial surgery. Otorhinolaryngologic surgery. Stomatology. Ophtalmology. Investigation and treatment technics</topic><topic>Pain - prevention & control</topic><topic>Pain Measurement</topic><topic>Pharmacology. Drug treatments</topic><topic>Prilocaine - administration & dosage</topic><topic>Time Factors</topic><topic>Tooth Extraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uckan, Sina</creatorcontrib><creatorcontrib>Guler, Nurhan</creatorcontrib><creatorcontrib>Sumer, Mahmut</creatorcontrib><creatorcontrib>Ungor, Mete</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uckan, Sina</au><au>Guler, Nurhan</au><au>Sumer, Mahmut</au><au>Ungor, Mete</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local anesthetic efficacy for oral surgery: Comparison of diphenhydramine and prilocaine</atitle><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>86</volume><issue>1</issue><spage>26</spage><epage>30</epage><pages>26-30</pages><issn>1079-2104</issn><eissn>1528-395X</eissn><abstract>Objective.
Diphenhydramine has been suggested as an alternative local anesthetic agent for patients claiming allergy to local anesthetics. The present study attempted to determine the local anesthetic efficacy of diphenhydramine for oral surgery.
Study design.
Seventeen patients claiming allergy to local anesthetics were given diphenhydramine as anesthetic alternative and compared with seven nonallergic control patients treated with prilocaine. After determining an average value of vitality score of neighboring and contralateral teeth by electrical pulp stimulation, molar and premolar teeth were extracted and postextraction vitality scores determined. Visual analogue scale, anesthesia onset times, and the incidence of pulpal and soft tissue anesthesia were analyzed nonparametrically by means of Mann-Whitney
U tests.
Results.
The mean onset time of pulp anesthesia with diphenhydramine (range, 4 to 7.5 minutes), excluding one failure, was not significantly different from that of prilocaine; (range, 4 to 13 minutes). The duration of anesthesia was significantly longer and the visual analogue scale lower in the group receiving prilocaine in comparison with the group receiving diphenhydramine.
Conclusion.
In the small group studied, diphenhydramine administration provided adequate anesthesia before oral surgery; it may be useful as an anesthetic alternative in patients with histories of allergy to local anesthetics.</abstract><cop>St. Louis, MO</cop><pub>Mosby, Inc</pub><pmid>9690241</pmid><doi>10.1016/S1079-2104(98)90145-7</doi><tpages>5</tpages></addata></record> |
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| ispartof | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 1998-07, Vol.86 (1), p.26-30 |
| issn | 1079-2104 1528-395X |
| language | eng |
| recordid | cdi_pubmed_primary_9690241 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adolescent Adult Anesthesia Anesthesia depending on type of surgery Anesthesia, Dental Anesthesia, Local Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Local - administration & dosage Anesthetics, Local - adverse effects Anesthetics. Neuromuscular blocking agents Bicuspid - surgery Biological and medical sciences Dental Pulp - drug effects Dental Pulp - physiology Diphenhydramine - administration & dosage Drug Hypersensitivity - etiology Electric Stimulation Female Humans Incidence Male Medical sciences Middle Aged Molar - surgery Molar, Third - surgery Neuropharmacology Orthopedic surgery. Maxillofacial surgery. Otorhinolaryngologic surgery. Stomatology. Ophtalmology. Investigation and treatment technics Pain - prevention & control Pain Measurement Pharmacology. Drug treatments Prilocaine - administration & dosage Time Factors Tooth Extraction |
| title | Local anesthetic efficacy for oral surgery: Comparison of diphenhydramine and prilocaine |
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