Induction of an Apoptotic Program in Cell-Free Extracts by 2-Chloro-2′-deoxyadenosine 5′-Triphosphate and Cytochrome c

Adenine deoxynucleosides, such as 2-chloro-2′-deoxyadenosine (2CdA) induce apoptosis in quiescent lymphocytes, and are thus useful drugs for the treatment of indolent lymphoproliferative diseases. However, it has remained puzzling why deoxyadenosine and its analogs are toxic to a cell that is not un...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-08, Vol.95 (16), p.9567-9571
Hauptverfasser:	Leoni, Lorenzo M., Chao, Qi, Cottam, Howard B., Genini, Davide, Rosenbach, Michael, Carrera, Carlos J., Budihardjo, Imawati, Wang, Xiaodong, Carson, Dennis A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Apoptotic Protease-Activating Factor 1 Biological Sciences Caspase 3 Caspases Cell free system Cells Cellular biology Cladribine - analogs & derivatives Cladribine - pharmacology Cultured cells Cysteine Endopeptidases - metabolism Cytochrome c Group - pharmacology Cytochromes Deoxyribonucleic acid DNA DNA fragmentation Enzyme Activation Experiments HeLa Cells Humans Lymphatic system Lymphocytes Lymphocytes - enzymology Memory interference Mitochondria - drug effects Nucleotides Proteins - metabolism Tumor Cells, Cultured
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