Treatment of severe veno-occlusive disease with defibrotide : Compassionate use results in response without significant toxicity in a high-risk population

Hepatic veno-occlusive disease (VOD) is the most common of the regimen-related toxicities accompanying stem cell transplantation (SCT). Despite aggressive therapies, including the combination of tissue plasminogen activator (t-PA) and heparin, severe VOD is almost uniformly fatal. Defibrotide (DF) i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood 1998-08, Vol.92 (3), p.737-744
Hauptverfasser:	RICHARDSON, P. G, ELIAS, A. D, SOIFFER, R, VREDENBURGH, J, LILL, M, WOOLFREY, A. E, BEARMAN, S. I, LACOBELLI, M, FAREED, J, GUINAN, E. C, KRISHNAN, A, WHEELER, C, NATH, R, HOPPENSTEADT, D, KINCHLA, N. M, NEUBERG, D, WALLER, E. K, ANTIN, J. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Bilirubin - blood Biological and medical sciences Cardiovascular system Child Child, Preschool Drug Evaluation Feasibility Studies Female Fibrinolytic Agents - adverse effects Fibrinolytic Agents - therapeutic use Hematopoietic Stem Cell Transplantation - adverse effects Hemorrhage - chemically induced Heparin - therapeutic use Hepatic Veno-Occlusive Disease - drug therapy Hepatic Veno-Occlusive Disease - mortality Humans Male Medical sciences Miscellaneous Multiple Organ Failure - prevention & control Neoplasms - mortality Neoplasms - therapy Palliative Care Pharmacology. Drug treatments Polydeoxyribonucleotides - adverse effects Polydeoxyribonucleotides - therapeutic use Receptors, Purinergic P1 - drug effects Retrospective Studies Risk Thalassemia - therapy Tissue Plasminogen Activator - therapeutic use Treatment Outcome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!